Data for Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish
The data set includes:
1) Swimbladder inflation at 120 hours post-fertilization (hpf)
2) Swimbladder surface area at 120 hpf
3) Larval body length at 120 hpf
4) Swimming activity at 120 hpf
5) Targeted whole body gene expression results for nine mRNA transcripts evaluated at 60 hpf (hb9; fgf10a; acta2; anxa5b; wnt5b; fzd2; shha; ihha; ptc1)
6) Targeted whole body gene expression results for the same nine mRNA transcripts evaluated at 120 hpf.
7) Whole body thyroid hormone concentrations measured at 48, 60, 96, and 120 hpf
8) Whole body thyroid hormone concentrations in IOP exposed embryos/larvae at 48, 60, and 120 hpf
9) Data for supplementary figures S6, S7A, S7B
10) Ratio T3 of IOP exposed embryos over control T3 levels during embryonic-juvenile development (4 replicates, Figure S9).
This dataset is associated with the following publication:
Van Dingenen, I., L. Vergauwen, A. Haigis, B. Blackwell, E. Stacy, D. Villeneuve, and D. Knapen. Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 261: 106632, (2023).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Daniel Villeneuve",
"hasEmail": "mailto:villeneuve.dan@epa.gov"
}
|
| description | The data set includes: 1) Swimbladder inflation at 120 hours post-fertilization (hpf) 2) Swimbladder surface area at 120 hpf 3) Larval body length at 120 hpf 4) Swimming activity at 120 hpf 5) Targeted whole body gene expression results for nine mRNA transcripts evaluated at 60 hpf (hb9; fgf10a; acta2; anxa5b; wnt5b; fzd2; shha; ihha; ptc1) 6) Targeted whole body gene expression results for the same nine mRNA transcripts evaluated at 120 hpf. 7) Whole body thyroid hormone concentrations measured at 48, 60, 96, and 120 hpf 8) Whole body thyroid hormone concentrations in IOP exposed embryos/larvae at 48, 60, and 120 hpf 9) Data for supplementary figures S6, S7A, S7B 10) Ratio T3 of IOP exposed embryos over control T3 levels during embryonic-juvenile development (4 replicates, Figure S9). This dataset is associated with the following publication: Van Dingenen, I., L. Vergauwen, A. Haigis, B. Blackwell, E. Stacy, D. Villeneuve, and D. Knapen. Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 261: 106632, (2023). |
| distribution |
[
{
"title": "Van Dingenen et al_AllData.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529156/Van%20Dingenen%20et%20al_AllData.xlsx"
}
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|
| identifier | https://doi.org/10.23719/1529156 |
| keyword |
[
"Adverse Outcome Pathways (AOPs)",
"endocrine disruption",
"fish",
"zebrafish"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2023-06-23 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1016/j.aquatox.2023.106632"
]
|
| rights |
null
|
| title | Data for Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish |
