Deiodinase 1 Screening of ToxCast Phase 1 Chemical Library
This excel spreadsheet contains the resultant data for over from inhibition assays with human Deiodinase 1 screened against the ToxCast Phase 1 chemical library and a few additional chemicals. Over 1800 chemicals were tested in total. It contains the list of chemicals tested and the median, minimum, and maximum inhibition for each chemical screened at 200 µM. Chemicals that gave greater than 50% inhibition were screened in concentration response mode, and the median, min, max inhibition at each concentration for those chemicals are included. Propylthiouracil was used in each plate as a positive control and the concentration-response data for those curves are also included.
This dataset is associated with the following publication:
Hornung, M., J. Korte, J. Olker, J. Denny, C. Knutsen, P. Hartig, M. Cardon, and S. Degitz. Screening the ToxCast Phase 1 chemical library for inhibition of deiodinase type 1 activity. TOXICOLOGICAL SCIENCES. Society of Toxicology, 162(2): 570-581, (2018).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Michael Hornung",
"hasEmail": "mailto:hornung.michael@epa.gov"
}
|
| description | This excel spreadsheet contains the resultant data for over from inhibition assays with human Deiodinase 1 screened against the ToxCast Phase 1 chemical library and a few additional chemicals. Over 1800 chemicals were tested in total. It contains the list of chemicals tested and the median, minimum, and maximum inhibition for each chemical screened at 200 µM. Chemicals that gave greater than 50% inhibition were screened in concentration response mode, and the median, min, max inhibition at each concentration for those chemicals are included. Propylthiouracil was used in each plate as a positive control and the concentration-response data for those curves are also included. This dataset is associated with the following publication: Hornung, M., J. Korte, J. Olker, J. Denny, C. Knutsen, P. Hartig, M. Cardon, and S. Degitz. Screening the ToxCast Phase 1 chemical library for inhibition of deiodinase type 1 activity. TOXICOLOGICAL SCIENCES. Society of Toxicology, 162(2): 570-581, (2018). |
| distribution |
[
{
"title": "20170817_DIO1_Phase1_InHouse.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1376911/20170817_DIO1_Phase1_InHouse.xlsx"
}
]
|
| identifier | https://doi.org/10.23719/1376911 |
| keyword |
[
"Chemical Screening",
"deiodinase",
"in vitro",
"thyroid hormone"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2017-08-16 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1093/toxsci/kfx279"
]
|
| rights |
null
|
| title | Deiodinase 1 Screening of ToxCast Phase 1 Chemical Library |
