• Organization: U.S. Environmental Protection Agency
• Updated: 2017-08-16

This excel spreadsheet contains the resultant data for over from inhibition assays with human Deiodinase 1 screened against the ToxCast Phase 1 chemical library and a few additional chemicals. ...

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2018-08-13

These excel spreadsheets contains the resultant data from inhibition assays with human Iodothyronine Deiodinase Types 1, 2, and 3 screened against the ToxCast Phase 1_v2, Phase 2, and e1k chemical...

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2020-06-10

The excel spreadsheet contains the resultant data from an assay for chemical inhibition of human Iodotyrosine Deiodinase (IYD) enzyme activity screened against the ToxCast Phase 1_v2, Phase 2, and...

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2023-03-31

Dataset for Nyffeler et al., 'Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments', Toxicology & Applied Pharmacology, Vol 468, 116513,...

• html
• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2021-07-26

All data associated with Figures and Tables of manuscript "CHEMICAL CHARACTERIZATION OF RECYCLED CONSUMER PRODUCTS USING SUSPECT SCREENING ANALYSIS", Charles Lowe et al., Environmental Science and...

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2019-08-08

The objective of this study was to develop a medium-throughput organotypic screening assay comprised of reconstructed human thyroid microtissues to quantitatively evaluate the disruptive effects...

• html
• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2022-02-02

This is an original dataset generated at the U.S. EPA. Data was analyzed with the ToxCast Pipeline and deposited for release in invitroDB accessible via the U.S. EPA CompTox Chemicals...

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2016-04-02

Disruption of steroidogenesis by environmental chemicals can result in altered hormone levels causing adverse reproductive and developmental effects. A high-throughput assay using H295R human...

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2025-03-25

Dataset for Jesse Rogers et al., 'Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening' published in Environmental Health...

• html
• html
• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2020-03-31

These are the raw data files for TOXSCI manuscript 19-0578 entitled, “Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical...

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2023-12-22

Abbreviations and data for manuscript Figures in the main text and supplemental. This dataset is associated with the following publication: Stoker, T., J. Want, A. Murr, J. Bailey, and A.R....

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2024-07-09

Dataset for Harrill, J.A. et al., 'Signature Analysis of High-Throughput Transcriptomics Screening Data for Mechanistic Inference and Chemical Grouping' published in Toxicological Sciences,...

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2016-04-01

High-throughput screening for potential thyroid-disrupting chemicals requires a system of assays to capture multiple molecular-initiating events (MIEs) that converge on perturbed thyroid hormone...

• html
• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2023-08-31

A full list of non-target chemical features found in the study "De facto water reuse - Investigating the fate and transport of chemicals of emerging concern from wastewater discharge through...

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2018-12-04

We created a consensus, meta-model using the Systematic Empirical Evaluation of Models framework in which the predictors of exposure were combined by pathway and weighted according to predictive...

• html
• html
• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2014-01-01

EPA researchers have been using advances in computational toxicology to address lack of data on the thousands of chemicals. EPA released chemical data on 1,800 chemicals. The 1,800 chemicals were...

• Organization: U.S. Environmental Protection Agency
• Updated: 2016-06-30

Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the food-relevant chemical universe...

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2023-12-12

Supporting information for "Phillips KA, Chao A, Church RL, Favela K, Garantziotis S, Isaacs KK, Meyer B, Rice A, Sayre R, Wetmore BA, Yau A, Wambaugh JF. Suspect Screening Analysis of Pooled...

• html
• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2022-02-01

Dataset for journal article 'Evaluation of 147 Perfluoroalkyl Substances for Immunosuppressive and other Activities Through Phenotypic Screening of Human Primary Cells'. Per- and polyfluoroalkyl...

• html

• Organization: U.S. Environmental Protection Agency
• Updated: 2022-02-25

The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxics10050256/s1. Figure S1, Effect of DMSO on Light/Dark Locomotor Activity; Figure S2, Time...

• html