Deiodinase Types 1, 2, and 3: Screening of ToxCast Phase 1_v2, Phase 2, and e1k Chemical Libraries
These excel spreadsheets contains the resultant data from inhibition assays with human Iodothyronine Deiodinase Types 1, 2, and 3 screened against the ToxCast Phase 1_v2, Phase 2, and e1k chemical libraries, as well as a few additional chemicals used in assay development. Over 1,800 chemicals were tested in total. It contains the list of chemicals tested and the median, minimum, and maximum inhibition for each chemical screened at 200 µM. Chemicals that gave greater than 50% inhibition were screened in concentration-response mode, and the median, min, max inhibition at each concentration for those chemicals are included. A model inhibitor (propylthiouracil or xanthohumol) was used in each plate as a positive control and the concentration-response data for those curves are also included.
This dataset is associated with the following publication:
Olker, J., J. Korte, J. Denny, P. Hartig, M. Cardon, C. Knutsen, P. Kent, J. Christensen, S. Degitz, and M. Hornung. Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 168(2): 430-442, (2019).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Jennifer Olker",
"hasEmail": "mailto:olker.jennifer@epa.gov"
}
|
| description | These excel spreadsheets contains the resultant data from inhibition assays with human Iodothyronine Deiodinase Types 1, 2, and 3 screened against the ToxCast Phase 1_v2, Phase 2, and e1k chemical libraries, as well as a few additional chemicals used in assay development. Over 1,800 chemicals were tested in total. It contains the list of chemicals tested and the median, minimum, and maximum inhibition for each chemical screened at 200 µM. Chemicals that gave greater than 50% inhibition were screened in concentration-response mode, and the median, min, max inhibition at each concentration for those chemicals are included. A model inhibitor (propylthiouracil or xanthohumol) was used in each plate as a positive control and the concentration-response data for those curves are also included. This dataset is associated with the following publication: Olker, J., J. Korte, J. Denny, P. Hartig, M. Cardon, C. Knutsen, P. Kent, J. Christensen, S. Degitz, and M. Hornung. Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 168(2): 430-442, (2019). |
| distribution |
[
{
"title": "Olker_et_al_DIO1_DIO2_DIO3_181127.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502542/Olker_et_al_DIO1_DIO2_DIO3_181127.xlsx"
}
]
|
| identifier | https://doi.org/10.23719/1502542 |
| keyword |
[
"Chemical Screening",
"In vitro assay",
"deiodinase",
"thyroid hormone"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2018-08-13 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1093/toxsci/kfy302"
]
|
| rights |
null
|
| title | Deiodinase Types 1, 2, and 3: Screening of ToxCast Phase 1_v2, Phase 2, and e1k Chemical Libraries |
