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Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes
This repository contains the necessary data, python source code and jupyter notebooks to reproduce the results from our manuscript, "Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes." Using in vitro data to estimate point of departure (POD) values is an important component of new approach method (NAM)-based chemical risk assessments. In this case study we evaluated a NAM for hepatotoxicity based on rat primary hepatocytes, high-content imaging (HCI) and in vitro to in vivo extrapolation (IVIVE).
This dataset is associated with the following publication:
Shah, I., T. Antonijevic, B. Chambers, J. Harrill, and R. Thomas. Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 183(2): 285-301, (2021).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Thomas Knudsen",
"hasEmail": "mailto:knudsen.thomas@epa.gov"
}
|
| description | This repository contains the necessary data, python source code and jupyter notebooks to reproduce the results from our manuscript, "Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes." Using in vitro data to estimate point of departure (POD) values is an important component of new approach method (NAM)-based chemical risk assessments. In this case study we evaluated a NAM for hepatotoxicity based on rat primary hepatocytes, high-content imaging (HCI) and in vitro to in vivo extrapolation (IVIVE). This dataset is associated with the following publication: Shah, I., T. Antonijevic, B. Chambers, J. Harrill, and R. Thomas. Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 183(2): 285-301, (2021). |
| distribution |
[
{
"title": "https://github.com/i-shah/heprn-hci-nam",
"accessURL": "https://github.com/i-shah/heprn-hci-nam"
}
]
|
| identifier | https://doi.org/10.23719/1520925 |
| keyword |
[
"hepatotoxicity",
"high-content imaging",
"new approach methodologies",
"pbtk",
"point of departure",
"repeat dose toxicity",
"tipping points",
"virtual embryo",
"virtual liver",
"virtual tissues"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2020-09-09 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1093/toxsci/kfab091"
]
|
| rights |
null
|
| title | Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes |
