Found 169 datasets matching "tipping points".
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Background: High-content imaging (HCI) allows simultaneous measurement of multiple cellular phenotypic changes and is an important tool for evaluating the biological activity of...
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To advance understanding of mangrove range dynamics in eastern North America, there is a need to refine temperature thresholds for mangrove freeze damage, mortality, and recovery. Here, We...
Search relevance: 66.35 | Views last month: 0 -
The attached zip file contains all of the source data, intermediate outputs and R-scripts used to calculate the tipping points reported in the Frank et al manuscript. This dataset is associated...
Search relevance: 57.72 | Views last month: 5 -
Background: Trends in male reproductive health have been reported for increased rates of testicular germ cell tumors, low semen quality, cryptorchidism, and hypospadias, which have been associated...
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Development of the neurovascular unit (NVU) is a complex, multistage process that requires orchestrated cell signaling mechanisms across several cell types and ultimately results in the formation...
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The data presented here support the application of the Stemina devTOXqP platform for predictive toxicology and further demonstrate its value in ToxCast as a novel resource that can generate...
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Biomarker Image Cytometry. The cell-level frequency of NK2 Homeobox 1 (NKX2-1), Keratin 7 (KRT7), and Thyroglobulin (TG) protein staining were quantitatively evaluated by high-content imaging...
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We differentiated human induced pluripotent stem cells (hiPSCs) to embryonic endoderm and sought to identify a tipping point at which the developing system did not recover from perturbations...
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Hypospadias is a developmental defect of urethral tube closure that has a complex etiology involving genetic and environmental factors, including anti-androgenic and estrogenic disrupting...
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The AOP concept was used to translate ToxCast high-throughput screening data into a ToxPi matrix of 1058 chemicals x 24 features ordered by predicted potential to disrupt angiogenesis. This...
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The objective of this study was to develop a medium-throughput organotypic screening assay comprised of reconstructed human thyroid microtissues to quantitatively evaluate the disruptive effects...
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Morphogenetic events are driven by cell-generated physical forces and complex cellular dynamics. To improve our capacity to predict developmental effects from cellular alterations, we built a...
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A data set of 500 chemicals evaluated for their ability to induce cleft palate in animal prenatal developmental studies was compiled from Toxicity Reference Database and the biomedical literature,...
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This repository contains the necessary data, python source code and jupyter notebooks to reproduce the results from our manuscript, "Estimating Hepatotoxic Doses Using High-content Imaging in...
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This layer represents the total effluent coming from onsite sewage disposal systems (OSDS) (e.g., cesspools and septic tanks). OSDS point data were obtained from the University of Hawaii at Manoa...
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This layer represents the nitrogen flux coming from onsite sewage disposal systems (OSDS) (e.g., cesspools and septic tanks). OSDS point data were obtained from the University of Hawaii at Manoa...
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This layer represents the phosphorus flux coming from onsite sewage disposal systems (OSDS) (e.g., cesspools and septic tanks). OSDS point data were obtained from the University of Hawaii at Manoa...
Search relevance: 43.33 | Views last month: 1 -
Chlorophyll-a is a widely used proxy for phytoplankton biomass and an indicator for changes in phytoplankton production. As an essential source of energy in the marine environment, the extent and...
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This layer represents a proxy for sediment input to the nearshore marine environment from recent construction sites. Data are derived from the NOAA Coastal Change Analysis Program (C-CAP) High...
Search relevance: 38.81 | Views last month: 1 -
Solar irradiance is one of the most important factors influencing coral reefs. As the majority of their nutrients are obtained from symbiotic photosynthesizing organisms, reef-building corals need...
Search relevance: 38.78 | Views last month: 0
