Evaluation of the potential effects of three chemicals on the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-gonadal (HPG) axes using the Larval Amphibian Growth and Development Assay (LAGDA)
Three chemicals, 2-ethylhexyl 4-hydroxybenzoate (2-EHHB), 5-chloro-2-(2,4-dichlorophenoxy) phenol (triclosan), and 4-nonylphenol, branched (4-NP) were evaluated using the Larval Amphibian Growth and Development Assay (LAGDA) to investigate endocrine-mediated effects. A delay in development to NF stage 62 was observed for the three chemicals, however, histopathological evaluation revealed that the effects were likely not thyroid related. 4-NP caused increased stage scores in male and female gonadal duct development. Citation information for this dataset can be found in Data.gov's References section.
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Alaa Kamel",
"hasEmail": "mailto:kamel.alaa@epa.gov"
}
|
| description | Three chemicals, 2-ethylhexyl 4-hydroxybenzoate (2-EHHB), 5-chloro-2-(2,4-dichlorophenoxy) phenol (triclosan), and 4-nonylphenol, branched (4-NP) were evaluated using the Larval Amphibian Growth and Development Assay (LAGDA) to investigate endocrine-mediated effects. A delay in development to NF stage 62 was observed for the three chemicals, however, histopathological evaluation revealed that the effects were likely not thyroid related. 4-NP caused increased stage scores in male and female gonadal duct development. Citation information for this dataset can be found in Data.gov's References section. |
| distribution |
[
{
"title": "Larval Amphibian Growth and Development Assay (LAGDA) of 2-Ethylhexyl 4-Hydroxybenzoate .docx",
"mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1532344/Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%202-Ethylhexyl%204-Hydroxybenzoate%20.docx"
},
{
"title": "Larval Amphibian Growth and Development Assay (LAGDA) of 4-nonylphenol.docx",
"mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1532344/Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%204-nonylphenol.docx"
},
{
"title": "Larval Amphibian Growth and Development Assay (LAGDA) of Triclosan.docx",
"mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1532344/Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%20Triclosan.docx"
}
]
|
| identifier | https://doi.org/10.23719/1532344 |
| keyword |
[
"2-Ethylhexyl 4-Hydroxybenzoate",
"4-nonylphenol",
"LAGDA",
"Triclosan",
"Xenopus",
"amphibian",
"endocrine disruption"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2025-06-09 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
|
| references |
[
"https://pasteur.epa.gov/uploads/10.23719/1532344/documents/Supplemental%20Spreadsheet%20S1%20a-c.xlsx"
]
|
| rights |
null
|
| title | Evaluation of the potential effects of three chemicals on the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-gonadal (HPG) axes using the Larval Amphibian Growth and Development Assay (LAGDA) |
