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Glucocorticoid Ligand Mixtures Bioassay 1

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Metadata Last Checked: August 02, 2025 | Last Modified: 2018-08-22
Raw data for glucocorticoid receptor ligand exposure experiments. This dataset is associated with the following publication: MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, and V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally detected receptor-ligand mixtures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 252-263, (2019).

Resources

43 resources available

  • 170330 MC27,176 hGR, fluocinonide, raw.xlsx

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  • 170330 MC27,176 hGR, fluocinonide, raw.xlsx

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  • 170330 MC27,176 hGR, fluticasone prop. raw.xlsx

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  • 170330 MC27,176, hGR, mLuc assay validation, fluocinonide.xlsx

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  • 170330 MC27,176, hGR, mLuc assay validation, fluticasone propionate.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • 170413 MC27,185, hGR, mLuc, 21-hydroprog.xlsx

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  • 170413 MC27,185, hGR, mLuc, flut. prop..xlsx

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  • 170630 QC.xlsx

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  • 170630 hGR, Aldosterone, raw.xlsx

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  • 170630 hGR, Flucinolone acetonide, raw.xlsx

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  • 170713 MC28,30 hGR Aldosterone, run3, raw.xlsx

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  • 170713 MC28,30 hGR Prednisone, raw.xlsx

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  • 170804 MC hGR assay valid flumethasone 300fM-100nM.xlsx

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  • 170811 MC28,46, hGR, mLuc, Flumethasone, run3.xlsx

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  • 170824 MC28,48 hGR FRMix1, raw.xlsx

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  • 170824 MC28,48 hGR GCCD, raw.xlsx

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  • CV1 Dex, 21-hydroxyprogesterone 2-2-2017.xlsx

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  • CV1 Dex, flucinonide 2-2-2017.xlsx

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  • CV1 Dex, flucinonide 3-2-2017.xlsx

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  • CV1a-hGR Dex and aldosterone 7-7-2017.xlsx

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  • CV1a-hGR Dex and betamethasone 5-25-2017.xlsx

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  • CV1a-hGR Dex and betamethasone 6-15-2017.xlsx

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  • CV1a-hGR Dex and betamethasone 6-8-2017.xlsx

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  • CV1a-hGR Dex and corticosterone 4-14-2017.xlsx

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  • CV1a-hGR Dex and cortisone 3-23-2017.xlsx

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  • CV1a-hGR Dex and cortisone 3-9-2017.xlsx

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  • CV1a-hGR Dex and cortisone 5-4-2017.xlsx

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  • CV1a-hGR Dex and dex-21-acetate 6-15-2017.xlsx

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  • CV1a-hGR Dex and dex-21-acetate 6-22-2017.xlsx

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  • CV1a-hGR Dex and flucinolone acetonide 7-13-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and flucinolone acetonide 7-7-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and flucinonide 3-9-2017.xlsx

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  • CV1a-hGR Dex and fludrocortisone 4-14-2017.xlsx

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  • CV1a-hGR Dex and fludrocortisone 5-25-2017.xlsx

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  • CV1a-hGR Dex and fluticasone propionate 3-9-2017.xlsx

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  • CV1a-hGR Dex coticosterone 4-6-2017.xlsx

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  • CV1a-hGR Dex, cortisone 4-6-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR p220 Dex and FRP45 7-7-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR p220 Dex and aldosterone 7-7-2017.xlsx

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  • CV1a-hGR p220 Dex and budesonide 7-7-2017-2.xlsx

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  • CV1a-hGR p220 Dex and budesonide 7-7-2017.xlsx

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  • Data Dictionary.pdf

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  • Data Summary By Figure.xlsx

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Complete Metadata
accessLevel public
bureauCode 
                                            [
  "020:00"
]
contactPoint 
                                            {
  "fn": "Elizabeth Medlock Kakaley",
  "hasEmail": "mailto:medlockkakaley.elizabeth@epa.gov"
}
description Raw data for glucocorticoid receptor ligand exposure experiments. This dataset is associated with the following publication: MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, and V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally detected receptor-ligand mixtures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 252-263, (2019).
distribution 
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    "title": "170330 MC27,176, hGR, mLuc assay validation, fluocinonide.xlsx",
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    "title": "170413 MC27,185, hGR, mLuc, 21-hydroprog.xlsx",
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    "title": "170630 QC.xlsx",
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    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502578/170630%20QC.xlsx"
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  {
    "title": "170630 hGR, Aldosterone, raw.xlsx",
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    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502578/170630%20hGR%2C%20Aldosterone%2C%20raw.xlsx"
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    "title": "170630 hGR, Flucinolone acetonide, raw.xlsx",
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    "title": "170713 MC28,30 hGR Aldosterone, run3, raw.xlsx",
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    "title": "170713 MC28,30 hGR Prednisone, raw.xlsx",
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    "title": "170804 MC hGR assay valid flumethasone 300fM-100nM.xlsx",
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    "title": "170811 MC28,46, hGR, mLuc, Flumethasone, run3.xlsx",
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    "title": "CV1 Dex, 21-hydroxyprogesterone 2-2-2017.xlsx",
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    "title": "CV1a-hGR Dex and aldosterone 7-7-2017.xlsx",
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]
identifier https://doi.org/10.23719/1502578
keyword 
                                            [
  "chemical mixtures",
  "effects-based screening",
  "generalized concentration addition model",
  "glucocorticoid receptor",
  "partial agonist"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2018-08-22
programCode 
                                            [
  "020:096"
]
publisher 
                                            {
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
                                            [
  "https://doi.org/10.1093/toxsci/kfy290"
]
rights 
                                            null
title Glucocorticoid Ligand Mixtures Bioassay 1

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