Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries

These are the raw data files for TOXSCI manuscript 19-0578 entitled, “Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries”: Description from readme.txt file: 1) sc_seahorse.lvl0.merged.data.csv- contains all mapped raw OCR data from tier 1 single-concentration RSA screening of 1,042 Toxcast Phase I and II chemicals 2) mc_seahorse.lvl0.merged.data.csv- contains all mapped raw OCR data from tier 2 multi-concentration RSA screening of 249 actives from tier 1 3) EFA.lvl0.merged.data.csv- contains all mapped raw OCR data from tier 3 EFA screening of 149 putative electron transport chain inhibitors 4) mc5_mc6_ncct_mito_nov2019.csv- level 5 and 6 outputs from ToxCast pipeline (tcpl) analysis 5) RawMC3_ToxCast_by_aeid.csv- level 3 tcpl outputs for all mitochondrial ToxCast assays 6) RawMC5_ToxCast_by_aeid.csv- level 5 tcpl outputs for all mitochondrial ToxCast assays 7) ref.set.chems.csv- sixty reference chemicals used to compared assay performance 8) study_code.R- R script used to analyze data and generate figures and tables. This dataset is associated with the following publication: Hallinger, D., H. Lindsay, K. Friedman, D. Suarez, and S. Simmons. Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 176(1): 175-192, (2020).

                                            [
  "020:00"
]
                                        

                                            {
  "fn": "Steven Simmons",
  "hasEmail": "mailto:simmons.steve@epa.gov"
}
                                        

                                            [
  {
    "title": "https://doi.org/10.5061/dryad.zkh189367",
    "accessURL": "https://doi.org/10.5061/dryad.zkh189367"
  }
]
                                        

                                            [
  "High throughput screening",
  "ToxCast"
]
                                        

                                            [
  "020:095"
]
                                        

                                            {
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
                                        

                                            [
  "https://doi.org/10.1093/toxsci/kfaa059",
  "https://doi.org/10.23645/epacomptox.12123735"
]
                                        

                                            null