The role of dorsal third ventricle α2 adrenergic antagonism or glucocorticoid antagonism in modulating the neuroendocrine stress response to acute ozone exposure
Dorsal third ventricle infusions of the alpha 2 adrenergic receptor antagonist, mianserin- which increases brain concentrations of dopamine, serotonin, and acetylcholine, or the glucocorticoid receptor antagonist, mifepristone, were performed in male WKY rats prior to acute ozone exposure at 0.8 ppm for 4 hours. This experiment was designed to target hippocampal and hypothalamic neuromodulation to determine the role of indoleamines, monoamines, and glucocorticoids in mediating the systemic and pulmonary effects to ozone exposure.
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Katherine Rentschler",
"hasEmail": "mailto:rentschler.katherine@epa.gov"
}
|
| description | Dorsal third ventricle infusions of the alpha 2 adrenergic receptor antagonist, mianserin- which increases brain concentrations of dopamine, serotonin, and acetylcholine, or the glucocorticoid receptor antagonist, mifepristone, were performed in male WKY rats prior to acute ozone exposure at 0.8 ppm for 4 hours. This experiment was designed to target hippocampal and hypothalamic neuromodulation to determine the role of indoleamines, monoamines, and glucocorticoids in mediating the systemic and pulmonary effects to ozone exposure. |
| distribution |
[
{
"title": "WKYICV-KR2024 Science Hub Mianserin and Mife Manuscript Updated 6.9.25.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1532349/WKYICV-KR2024%20Science%20Hub%20Mianserin%20and%20Mife%20Manuscript%20Updated%206.9.25.xlsx"
}
]
|
| identifier | https://doi.org/10.23719/1532349 |
| keyword |
[
"Catecholamines",
"Ozone",
"air pollution",
"glucocorticoids",
"monoamines",
"neuroendocrine stress axes",
"pulmonary injury"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2025-06-09 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
null
|
| rights |
null
|
| title | The role of dorsal third ventricle α2 adrenergic antagonism or glucocorticoid antagonism in modulating the neuroendocrine stress response to acute ozone exposure |
