Found 44 datasets matching "Adverse outcome pathways".
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A set of three proposed "hub" key events were used to link together a series of example adverse outcome pathway (AOP) descriptions that were previously not linked in an AOP network. While there...
Search relevance: 233.08 | Views last month: 0 -
Metabolite Input Files for Determining Biochemical Pathways Impacted by Spironolactone Exposures of Fathead Minnows (Pimephales promelas) Using the Mummichog Software package. This dataset is...
Search relevance: 218.48 | Views last month: 0 -
Ongoing honey bee colony losses are of significant international concern because of the essential role these insects play in pollinating many high nutrient crops, such as fruits, vegetables, and...
Search relevance: 183.91 | Views last month: 3 -
Fathead minnows (Pimephales promelas) were exposed to 100 ug/L indomethacin, 200 ug/L ibuprofen, or 20 ug/L celecoxib for 96 h. Effects on cycloxygenase enzyme activity in ovary, prostaglandin...
Search relevance: 176.15 | Views last month: 2 -
A publised mansucript describing a quantitative adverse outcome pathway (qAOP) and its relevance to risk assessment. This dataset is not publicly accessible because: This work describes...
Search relevance: 152.70 | Views last month: 0 -
Serum and brain thyroid hormone measurements in rat brain. This dataset is associated with the following publication: Gilbert, M., J. Ford, C. Riutta, K. OShaughnessy, and P.A. Kosian. Reducing...
Search relevance: 145.87 | Views last month: 0 -
As a case study, chemical occurrence data from a 2012 study in the Great Lakes Basin along with the ToxCast™ effects database were used to calculate exposure-activity ratios (EARs) as a...
Search relevance: 78.66 | Views last month: 0 -
This ScienceHub entry provides Associated Data (Supplementary data 1) from the published manuscript Comput Toxicol. 2023 Jan 25;25:100261. doi: 10.1016/j.comtox.2023.100261. Further availability...
Search relevance: 72.62 | Views last month: 0 -
Dataset includes whole proteome results following acute kainic acid exposure in adult Long Evans rats. Samples are ex vivo brain tissues, specifically the hippocampus, cortex, and cerebellum...
Search relevance: 71.06 | Views last month: 8 -
The data set includes: 1) Swimbladder inflation at 120 hours post-fertilization (hpf) 2) Swimbladder surface area at 120 hpf 3) Larval body length at 120 hpf 4) Swimming activity at 120 hpf 5)...
Search relevance: 70.90 | Views last month: 0 -
Nerve Excitability, Body Weight, Functional Observational Battery, Histology, and raw Lipidomics data after single exposure to 0, 3, 4.4 or 6.5 mg/kg triethyl tin.
Search relevance: 70.80 | Views last month: 0 -
Dataset includes all endpoint measurements from studies described in the manuscript and SAS code for statistical analyses of data. This dataset is associated with the following...
Search relevance: 69.96 | Views last month: 1 -
The dataset includes data from six experiments in which adult male fathead minnows were exposed to five concentrations of a per- or polyfluorinated alkyl substance (PFAS) and a 17beta-estradiol...
Search relevance: 69.36 | Views last month: 2 -
The data set consists of the following: 1) AOP-Wiki xml downloads from March 2022 used in constructing and evaluating the AOP network. 2) A literature database containing all literature that was...
Search relevance: 69.36 | Views last month: 0 -
Uterotrophic assay data analysis from gene arrays and uterine weights. This dataset is associated with the following publication: Dixon, A., E. Rowan, A. Yackley, and E. Hines. PFAS Modulate...
Search relevance: 69.27 | Views last month: 0 -
This dataset contains results from rodent study. Thyroid hormones and brain endpoints are reported for pregnant rat dams and progeny on gestational day 20 following drinking water exposure to the...
Search relevance: 69.14 | Views last month: 1 -
Data on hormone and chemical analysis is included for the effects of oxyfluorfen on thyroid hormones in the 4- and 8-day exposed juvenile rats. This dataset is associated with the following...
Search relevance: 68.79 | Views last month: 0 -
Data set includes empirical results from 60 h, 10 d, and 21 d exposures of female fathead minnows to the fungicide imazalil as well as simulations from predictive models anchored to an established...
Search relevance: 67.70 | Views last month: 0 -
Dataset of medium throughput (96 well plate) in vitro nuclear receptor activation assays for peroxisome proliferator activated receptor alpha (PPARa), PPAR gamma (PPARg), and estrogen receptor...
Search relevance: 67.15 | Views last month: 0
