• Organization: U.S. Environmental Protection Agency
• Updated: 2025-04-07

Dataset for S. Sakamuru, et al., 'Profiling the Tox21 Compound Library for Their Inhibitory Effects on Cytochrome P450 Enzymes' published in Int'l Journal of Molecular Sciences, DOI...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background The search for an optimal experimental model in pharmacology is recently focused on (mini)pigs as they seem not only to be an alternative source of cells and tissues for...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background Nasopharyngeal carcinoma (NPC) is a rare tumor in most parts of the world but occurs at relatively high frequency among people of Chinese descent. The cytochrome P450 2E1...

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• Organization: U.S. Environmental Protection Agency
• Updated: 2018-12-13

There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme involved in the...

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• Organization: U.S. Environmental Protection Agency
• Updated: 2021-03-10

The raw values used to create figures 1 and 2 and table 3. This dataset is associated with the following publication: Liu, J., Y. Lu, C. Corton, and C. Klaassen. Expression of cytochrome P450...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background Availability of genomewide information on an increasing but still limited number of plants offers the possibility of identifying orthologues, or related genes, in species with...

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• Organization: Department of Agriculture
• Updated: 2024-02-15

The ascomycete fungus Cryphonectria parasitica is the causal agent of chestnut blight disease. This deadly fungal pathogen was introduced into North America from Asia before the turn of the 20th...

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• Organization: National Oceanic and Atmospheric Administration, Department of Commerce
• Updated: 2006-10-01T00:00:00.000+00:00

This study was based on the sediment quality triad (SQT) approach. A stratified probabilistic sampling design was utilized to characterize the Delaware Bay system in terms of chemical...

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• Organization: National Oceanic and Atmospheric Administration, Department of Commerce
• Updated: 2008-05-01T00:00:00.000+00:00

This study was based on the sediment quality triad (SQT) approach. A stratified probabilistic sampling design was utilized to characterize the San Francisco Bay system in terms of chemical...

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• Organization: National Oceanic and Atmospheric Administration, Department of Commerce
• Updated: 2006-01-01T00:00:00.000+00:00

This study was based on the sediment quality triad (SQT) approach. A stratified probabilistic sampling design was utilized to characterize the Chesapeake Bay system in terms of chemical...

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• Organization: National Oceanic and Atmospheric Administration, Department of Commerce
• Updated: 2014-06-03T00:00:00.000+00:00

This study was based on the sediment quality triad (SQT) approach. A stratified probabilistic sampling design was utilized to characterize the Delaware Bay system in terms of chemical...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Tavneos (avacopan) is an oral prescription capsule containing 10 mg of avacopan, manufactured by ChemoCentryx, Inc. It acts as a complement 5a receptor antagonist and cytochrome P450 3A4...

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• Organization: National Oceanic and Atmospheric Administration, Department of Commerce
• Updated: 2006-08-15T00:00:00.000+00:00

The foundation of this study was based on a sediment quality triad (SQT) approach with a probabilistic sampling design, which characterized the estuary in terms of chemical contamination in...

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• Organization: U.S. Environmental Protection Agency
• Updated: 2019-12-10

Most of the data illustrates the effects that some e-cigarette flavoring agents, as well as some of the chemical components of those flavoring agents, directly have on the cytochrome P450 2A6...

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• Organization: U.S. Environmental Protection Agency
• Updated: 2021-03-25

This ScienceHub dataset provides characterization data for a pooled sample of trout liver S9 fractions that was used to study the in vitro intrinsic clearance of selected cationic surfactants. ...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered....

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• Organization: U.S. Environmental Protection Agency
• Updated: 2017-10-16

The US EPA’s ToxCast program is designed to assess chemical perturbations of molecular and cellular endpoints using a variety of high-throughput screening (HTS) assays. However, existing HTS...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

The risks and benefits of stopping antiretroviral therapy in patients admitted to the ICU are largely unmeasured. In many cases therapy has to be stopped, as parenteral preparations are...

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• Organization: Department of Agriculture
• Updated: 2025-11-20

A honey bee queen ability to produce eggs is critical to the function of a colony, yet little is known regarding the effects of stress on oviposition or the physiological processes underpinning...

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• Organization: U.S. Environmental Protection Agency
• Updated: 2020-08-24

The objective of this study was to develop an approach to retrofit existing HTS assays with hepatic metabolism. The Alginate Immobilization of Metabolic Enzymes (AIME) platform encapsulates...

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