Found 63 datasets matching "antagonist".
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Background Antagonistic analogues of GnRH for the treatment of prostate cancer may be used clinically in persons for whom return to fertility after such treatment is important or...
Search relevance: 135.65 | Views last month: 2 -
Background It is well established that ACE-inhibitors should be avoided in patients with renal artery stenosis. In recent years it has also been recommended that caution should be...
Search relevance: 119.46 | Views last month: 0 -
Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds....
Search relevance: 99.62 | Views last month: 0 -
Interleukin-1 receptor antagonist (IL-1Ra) is a natural IL-1 inhibitor possessing anti-inflammatory properties. IL-1Ra is produced as different isoforms, one secreted (sIL-1Ra) and three...
Search relevance: 83.52 | Views last month: 0 -
Background: The aim of this study was to compare pre-arrest and post-resuscitation organ perfusion values and to investigate whether, during the post-resuscitation phase, administration...
Search relevance: 79.14 | Views last month: 1 -
Background Animal and organ culture experiments have shown beneficial inhibitory estrogen effects on post injury neointima development. The purpose of this study was to investigate...
Search relevance: 75.53 | Views last month: 0 -
The production of superantigenic exotoxins by Gram positive bacteria underlies the pathology of toxic shock syndrome. Future treatment strategies for superantigen-mediated diseases are likely to...
Search relevance: 74.80 | Views last month: 0 -
This dataset is from screening 94 diverse chemicals for estrogen receptor (ER) activation in a competitive rainbow trout ER binding assay and a trout liver slice vitellogenin mRNA expression...
Search relevance: 66.14 | Views last month: 0 -
In recent years, the effectiveness of anti-TNF therapy in treating rheumatoid arthritis (RA) has become apparent. While trials of IL-1 receptor antagonist in RA have been encouraging, it clearly...
Search relevance: 60.62 | Views last month: 0 -
Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of...
Search relevance: 59.51 | Views last month: 0 -
Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are considered to be master cytokines in chronic, destructive arthritis. Therapeutic approaches in rheumatoid arthritis (RA) patients have so...
Search relevance: 58.90 | Views last month: 1 -
Background Lerisetron, a competitive serotonin type 3 receptor (5-HT3R) antagonist, contains five functional groups capable of interacting with amino acids in the 5-HT3R binding site....
Search relevance: 58.41 | Views last month: 0 -
Chemical patent from PubChem database. Patent Number: AT-E400555-T1. Title: Method of Treatment Using Chemical Compounds. Filing Date: 2000-04-17. Inventors: Smith, John A., Johnson, Mary B.....
Search relevance: 57.37 | Views last month: 1 -
Chemical patent from PubChem database. Patent Number: AT-E400254-T1. Title: Pharmaceutical Formulation and Method of Use. Filing Date: 2013-01-26. Inventors: Wilson, James, Brown, Patricia, Lee,...
Search relevance: 57.11 | Views last month: 0 -
Chemical patent from PubChem database. Patent Number: AT-E400556-T1. Title: Combinatorial Chemistry Method. Filing Date: 2001-11-07. Inventors: Kim, Young-Soo, Taylor, Elizabeth. Abstract: A...
Search relevance: 50.75 | Views last month: 0 -
The aim of this study was to investigate temporal changes in the hypothalamic-pituitary-gonadal axis of fathead minnow treated with the model androgen receptor (AR) antagonist, flutamide....
Search relevance: 45.76 | Views last month: 0 -
The present invention relates to a process for the manufacture of compounds of formula Ia or Ib and pharmaceutically acceptable additional salts thereof, wherein R is lower alkyl. The compounds of...
Search relevance: 44.76 | Views last month: 0 -
Dorsal third ventricle infusions of the alpha 2 adrenergic receptor antagonist, mianserin- which increases brain concentrations of dopamine, serotonin, and acetylcholine, or the glucocorticoid...
Search relevance: 44.08 | Views last month: 0 -
It is intended to provide a novel receptor of LPA and a method of screening a drug such as an LPA receptor antagonist using the same. Use as a lysophosphatidic acid (LPA) receptor comprising a G...
Search relevance: 43.72 | Views last month: 0 -
Background The pathophysiology behind spina bifida and other neural tube defects (NTDs) is unclear. Folic acid is one variable, but other factors remain. Studies suggest that substances...
Search relevance: 43.43 | Views last month: 0
