Found 13 datasets matching "aromatase".
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There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme involved in the...
Search relevance: 136.27 | Views last month: 1 -
Adverse outcome pathway (AOP) networks potentially provide a basis for predictive approaches to assess the toxicity of chemical mixtures. This study evaluated the utility of a simple AOP network...
Search relevance: 122.20 | Views last month: 0 -
This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal (in vivo) responses to...
Search relevance: 101.46 | Views last month: 2 -
Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect aromatase inhibition are part of...
Search relevance: 97.20 | Views last month: 1 -
Predictive models and frameworks for linking inhibition of the enzyme aromatase, as measured in non-animal high throughput screening assays, to adverse effects on reproduction in fish have been...
Search relevance: 94.32 | Views last month: 0 -
6-Substituted androsta-1,4-diene-3,17-dione derivatives of formula (I) nn whereinn R is (1) the group-N3;n (2) a group nn wherein each of r1 and R2 is, independently, hydrogen or unsaturated...
Search relevance: 94.18 | Views last month: 0 -
Data used in the creation of each figure and table cited in Doering et al. (2019; DOI: 10.1021/acs.est.9b02606) are provided. This dataset is associated with the following publication: Doering,...
Search relevance: 84.53 | Views last month: 0 -
Data set includes empirical results from 60 h, 10 d, and 21 d exposures of female fathead minnows to the fungicide imazalil as well as simulations from predictive models anchored to an established...
Search relevance: 74.47 | Views last month: 0 -
Exemestane is a prescription medication available as 25 mg oral tablets, manufactured by Breckenridge Pharmaceutical, Inc. It belongs to the aromatase inhibitor class and is used to treat hormone...
Search relevance: 42.19 | Views last month: 0 -
This data set describes experiments that were conducted to investigate whether exposure of male fathead minnows to environmentally-relevant estrone concentrations would result in elevated plasma...
Search relevance: 31.57 | Views last month: 0 -
Previous work identified a ‘cytotoxic burst’ (CTB) phenomenon wherein large numbers of the ToxCast assays begin to respond at or near test chemical concentrations that elicit cytotoxicity, and a...
Search relevance: 28.59 | Views last month: 1 -
Triclocarban (TCC) is a widely used antimicrobial agent that is routinely detected in surface waters. The present study was designed to examine TCC’s efficacy and mode of action as a reproductive...
Search relevance: 23.96 | Views last month: 1
