Adverse Outcome Pathway Network-Based Assessment of the Interactive Effects of an Androgen Receptor Agonist and an Aromatase Inhibitor on Fish Endocrine Function
Adverse outcome pathway (AOP) networks potentially provide a basis for predictive approaches to assess the toxicity of chemical mixtures. This study evaluated the utility of a simple AOP network to predict the interactive effects of a binary chemical mixture comprised of an inhibitor of the aromatase enzyme (fadrozole, a human pharmaceutical) and an agonist of the androgen receptor (trenbolone, a veterinary drug). Overall, prediction of interactive effects of the two chemicals based on the AOP network did not match actual observed effects. Rather, the two compounds seemed to interact in an independent manner in terms of their effects on the hypothalamic-pituitary-gonadal axis in the fish.
This dataset is associated with the following publication:
Ankley, G., B. Blackwell, J. Cavallin, J. Doering, D.J. Feifarek, K. Jensen, M. Kahl, C. Lalone, S. Poole, E. Randolph, T. Saari, and D. Villeneuve. Adverse outcome pathway network-based assessment of the interactive effects of an androgen receptor agonist and an aromatase inhibitor on fish endocrine function. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 39(4): 913-922, (2020).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Gerald Ankley",
"hasEmail": "mailto:ankley.gerald@epa.gov"
}
|
| description | Adverse outcome pathway (AOP) networks potentially provide a basis for predictive approaches to assess the toxicity of chemical mixtures. This study evaluated the utility of a simple AOP network to predict the interactive effects of a binary chemical mixture comprised of an inhibitor of the aromatase enzyme (fadrozole, a human pharmaceutical) and an agonist of the androgen receptor (trenbolone, a veterinary drug). Overall, prediction of interactive effects of the two chemicals based on the AOP network did not match actual observed effects. Rather, the two compounds seemed to interact in an independent manner in terms of their effects on the hypothalamic-pituitary-gonadal axis in the fish. This dataset is associated with the following publication: Ankley, G., B. Blackwell, J. Cavallin, J. Doering, D.J. Feifarek, K. Jensen, M. Kahl, C. Lalone, S. Poole, E. Randolph, T. Saari, and D. Villeneuve. Adverse outcome pathway network-based assessment of the interactive effects of an androgen receptor agonist and an aromatase inhibitor on fish endocrine function. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 39(4): 913-922, (2020). |
| distribution |
[
{
"title": "Interactive effects of an androgen receptor agonist (trenbolone) and aromatase inhibitor (fadrozole) dataset final.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1504080/Interactive%20effects%20of%20an%20androgen%20receptor%20agonist%20%28trenbolone%29%20and%20aromatase%20inhibitor%20%28fadrozole%29%20%20dataset%20final.xlsx"
}
]
|
| identifier | https://doi.org/10.23719/1504080 |
| keyword |
[
"17-beta-trenbolone",
"Androgen receptor",
"Aromatase inhibitor",
"adverse outcome pathway",
"aquatic ecosystems",
"ecotoxicology",
"endocrine disruption",
"fadrozole",
"fathead minnow",
"screening and prioritization"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2019-07-17 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1073/pnas"
]
|
| rights |
null
|
| title | Adverse Outcome Pathway Network-Based Assessment of the Interactive Effects of an Androgen Receptor Agonist and an Aromatase Inhibitor on Fish Endocrine Function |
