Found 25 datasets matching "cd4-t-cells".
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The aim of this study was to analyze the differential effects of three anti-CD4 monoclonal antibodies (mAbs) (with distinct epitope specifities) in the treatment of rat adjuvant arthritis (AA) and...
Search relevance: 173.47 | Views last month: 0 -
IL-10, IL-13, IFN-γ, tumor necrosis factor (TNF)-α, LT-α, CD154, and TNF-related activation-induced cytokine (TRANCE) were expressed by 2-20% of rheumatoid arthritis (RA) synovial tissue CD4+...
Search relevance: 169.79 | Views last month: 0 -
Most techniques that identify antigen-specific T cells are dependent on the response of these cells to the relevant antigen in culture. Soluble multimers of MHC molecules, when occupied with the...
Search relevance: 166.13 | Views last month: 0 -
Background Plasmodium falciparum erythrocyte membrane protein-1, a variant antigen of the malaria parasite, is potentially a target for the immune response. It would be important to...
Search relevance: 161.51 | Views last month: 0 -
Inflammatory responses provoked by pathogens are antigen-specific in their induction but are nonspecific in their effects. Consequently, they are potentially damaging to the host that produces...
Search relevance: 158.01 | Views last month: 0 -
Twenty-four yearling Angus-dairy cross heifers were housed in an outdoor facility at the National Animal Disease Center (NADC) in Ames, Iowa. Heifers were vaccinated subcutaneously with one of...
Search relevance: 155.37 | Views last month: 0 -
CD4+ memory T cells (Tm) from rheumatoid arthritis peripheral blood (RAPB) or peripheral blood from normal donors produced IL-2, whereas fewer cells secreted IFN-γ or IL-4 after a brief...
Search relevance: 149.13 | Views last month: 0 -
Regulatory T cells prevent autoimmunity by suppressing the reactivity of potentially aggressive self-reactive T cells. Contact-dependent CD4+ CD25+ 'professional' suppressor cells and other...
Search relevance: 111.08 | Views last month: 1 -
Most patients with rheumatoid arthritis (RA) express HLA-DR4, HLA-DR1 or HLA-DR10. These alleles share a common amino acid motif in their third hypervariable regions: the shared epitope. In...
Search relevance: 107.04 | Views last month: 0 -
Background Intrathymic development and selection of the T lymphocyte repertoire is restricted by the interactions of the T cell antigen receptor and CD4 or CD8 co-receptors with self...
Search relevance: 91.95 | Views last month: 0 -
After activation CD4+ helper T cells differentiate into T-helper (Th) 1 or Th2 effector cells. These two subsets are characterized by their distinct cytokine expression pattern and the immune...
Search relevance: 90.36 | Views last month: 1 -
Background T cells from HIV+ and aged individuals show parallels in terms of suppressed proliferative activity and interleukin-2 (I1-2) production and an increased number of CD8+ CD28- T...
Search relevance: 90.29 | Views last month: 1 -
A study was done to determine if the differentiation and activation phenotype of T cells in synovial fluid (SF) from patients with juvenile idiopathic arthritis (JIA) is associated with T-cell...
Search relevance: 88.57 | Views last month: 0 -
This dataset contains files reconstructing single-cell data presented in 'Reference transcriptomics of porcine peripheral immune cells created through bulk and single-cell RNA sequencing' by...
Search relevance: 88.11 | Views last month: 0 -
Background Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-defective adenoviral...
Search relevance: 82.31 | Views last month: 0 -
Accumulating data support the concept that ionizing radiation therapy (RT) has the potential to convert the tumor into an in situ individualized vaccine; however this potential is rarely realized...
Search relevance: 78.46 | Views last month: 0 -
Background The development and activation of CD4+ helper T cell (Th) subsets with distinct patterns of unbalanced production of cytokines play an important part in infectious, allergic...
Search relevance: 78.39 | Views last month: 1 -
Accumulating data support the concept that ionizing radiation therapy (RT) has the potential to convert the tumor into an in situ individualized vaccine; however this potential is rarely realized...
Search relevance: 76.62 | Views last month: 0 -
Files pertaining to data analyses performed and presented in the preprint, 'Porcine intestinal innate lymphoid cells and lymphocyte spatial context revealed through single-cell RNA sequencing' by...
Search relevance: 73.42 | Views last month: 0 -
Background Various microbial, inflammatory and immune signals regulate the activation of dendritic cells (DC), determining their ability to interact with naïve T cells and to produce...
Search relevance: 71.94 | Views last month: 0
