• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background In addition to immune cells, many other cell types are known to produce cytokines. Cultured normal mouse gallbladder epithelial cells, used as a model system for gallbladder...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Recent work has established that IL-1β plays a central role in the inflammation and connective tissue destruction observed in both rheumatoid arthritis and osteoarthritis. These processes result...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Response to Fionula Brennan's Commentary "A follow-up to 'Anti-cytokine therapy in chronic destructive arthritis' by Wim B van den Berg"

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• Organization: Department of Agriculture
• Updated: 2024-02-08

A GeXP multiplex, RT-PCR assay was developed and optimized that simultaneously measures expression of a suite of immune-relevant genes in rainbow trout (Oncorhynchus mykiss), concentrating on...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

The cytokine tumour necrosis factor (TNF)α is a vital mediator of the innate immune response, and a pleiotropic regulator of cellular function. Its involvement in rheumatoid arthritis is...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

Radiation affects tissue and cellular integrity at the level of DNA protein and metabolites of the cell and extracellular space. The effects of radiation are not limited to targeted cells and...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Tumor necrosis factor-α (TNF-α) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology,...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage; this is a committed step in the progression of rheumatoid arthritis and...

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• Organization: Department of Agriculture
• Updated: 2025-11-21

An experimental challenge of Influenza A virus in genetically modified TMPRSS2 knockout pigs. Resources in this dataset: Resource Title: Pigs lacking TMPRSS2 displayed fewer lung lesions and...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background It has been proposed that outer surface protein A (OspA) of Borrelia burgdorferi sensu stricto contains a T helper 1 (Th1) cell epitope that could play a role in an autoimmune...

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• Organization: U.S. Environmental Protection Agency
• Updated: 2012-04-15

These data are from a human study collected under IRB protocol: ClinicalTrials.gov # NCT01874834. This dataset is not publicly accessible because: EPA cannot release personally identifiable...

• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background: Haemodynamic instability is common in septic patients with acute renal failure. Continuous veno-venous haemodiafiltration (CVVHD) is therefore used as an alternative...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background Guolin Qigong is a combination of meditation, controlled breathing and physical movement designed to control the vital energy (qi) of the body and consequently to improve...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Interleukin-1 receptor antagonist (IL-1Ra) is a natural IL-1 inhibitor possessing anti-inflammatory properties. IL-1Ra is produced as different isoforms, one secreted (sIL-1Ra) and three...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

After activation CD4+ helper T cells differentiate into T-helper (Th) 1 or Th2 effector cells. These two subsets are characterized by their distinct cytokine expression pattern and the immune...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background T cells from HIV+ and aged individuals show parallels in terms of suppressed proliferative activity and interleukin-2 (I1-2) production and an increased number of CD8+ CD28- T...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background The present paper aims at studying the role of B7/CD28 interaction and related cytokine production in the immunological changes after exposure to different doses of ionizing...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

['The visual impairment and intracranial pressure (VIIP) syndrome is a neuro-ophthalmologic condition described in astronauts returning from long duration space missions. Idiopathic intracranial...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

['The visual impairment and intracranial pressure (VIIP) syndrome is a neuro-ophthalmologic condition described in astronauts returning from long duration space missions. Idiopathic intracranial...

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