Found 36 datasets matching "fibroblast".
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Fibroblast-like cells in the synovial lining (type B lining cells), stroma and pannus tissue are targeted by many signals, such as the following: ligands binding to cell surface receptors; lipid...
Search relevance: 155.03 | Views last month: 1 -
Fibroblast biology: Synovial fibroblasts in rheumatoid arthritis - leading role or chorus line?
Search relevance: 139.82 | Views last month: 0 -
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various...
Search relevance: 124.84 | Views last month: 0 -
There is mounting evidence indicating that the synovial fibroblast is a direct effector of tissue injury and matrix remodeling in inflammatory synovitis. Through the elaboration of effector...
Search relevance: 107.78 | Views last month: 0 -
There is growing evidence that activated synovial fibroblasts, as part of a complex cellular network, play an important role in the pathogenesis of rheumatoid arthritis. In recent years,...
Search relevance: 88.61 | Views last month: 0 -
Background Inflammatory cells are believed to play a prominent role during tissue repair and remodeling. Since repair processes develop and mature over extended time frames, the present...
Search relevance: 60.60 | Views last month: 0 -
Microgravity or an altered gravity environment from the static 1g has been shown to influence global gene expression patterns and protein levels in cultured cells or animals, but it is unclear how...
Search relevance: 59.77 | Views last month: 0 -
Synovial fibroblasts occur as two phenotypes - intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell...
Search relevance: 59.56 | Views last month: 0 -
Exposure to radiation provokes cellular responses controlled in part by gene expression networks. MicroRNAs (miRNAs) are small non-coding RNAs which mostly regulate gene expression by degrading...
Search relevance: 59.34 | Views last month: 0 -
Background SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the...
Search relevance: 56.64 | Views last month: 0 -
Exposure to radiation provokes cellular responses controlled in part by gene expression networks. MicroRNAs (miRNAs) are small non-coding RNAs which mostly regulate gene expression by degrading...
Search relevance: 54.94 | Views last month: 0 -
Mitochondrial DNA-depleted human skin fibroblasts (HSF rho0) with suppressed oxidative phosphorylation were characterized by significant changes in the expression of 2100 nuclear genes encoding...
Search relevance: 54.94 | Views last month: 0 -
Using a novel flood source construct we performed a direct comparison of genome-wide gene expression regulations resulting from exposure of primary human prostate fibroblast cultures to acute...
Search relevance: 40.79 | Views last month: 0 -
Mesenchymal precursor cells found in the blood (BMPCs) of normal persons adhere to plastic and glass and proliferate logarithmically in DMEM-20% fetal calf serum (FCS) without growth factors. They...
Search relevance: 39.14 | Views last month: 1 -
The transcription factor NF-κB has been well recognized as a pivotal regulator of inflammation in rheumatoid arthritis (RA), but recent developments revealed a broad involvement of NF-κB in other...
Search relevance: 38.50 | Views last month: 0 -
To understand gene expression responses in confluent human fibroblast in microgravity conditions to bleomycin treatment. Confluent human fibroblasts AG01522 were flown to the International Space...
Search relevance: 37.97 | Views last month: 0 -
The identification of angiogenic growth factors, such as vascular endothelial growth factor and fibroblast growth factor, has fueled interest in using such factors to induce therapeutic...
Search relevance: 35.74 | Views last month: 0 -
Mechanisms whereby T lymphocytes contribute to synovial inflammation in rheumatoid arthritis are poorly understood. Here we review data that indicate an important role for cell contact between...
Search relevance: 35.35 | Views last month: 1 -
The matricellular protein thrombospondin 2 (TSP2) regulates a variety of cell–matrix interactions. A prominent feature of TSP2-null mice is increased microvascular density, particularly in...
Search relevance: 35.22 | Views last month: 0 -
The reaction patterns of chondrocytes in osteoarthritis can be summarized in five categories: (1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and (3) degradation;...
Search relevance: 34.61 | Views last month: 1
