Cell-cell interactions in synovitis: Interactions between T lymphocytes and synovial cells
Mechanisms whereby T lymphocytes contribute to synovial inflammation in rheumatoid arthritis are poorly understood. Here we review data that indicate an important role for cell contact between synovial T cells, adjacent macrophages and fibroblast-like synoviocytes (FLS). Thus, T cells activated by cytokines, endothelial transmigration, extracellular matrix or by auto-antigens can promote cytokine, particularly TNFα, metalloproteinase production by macrophages and FLS through cell-membrane interactions, mediated at least through β-integrins and membrane cytokines. Since soluble factors thus induced may in turn contribute directly to T cell activation, positive feedback loops are likely to be created. These novel pathways represent exciting potential therapeutic targets.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
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| description | Mechanisms whereby T lymphocytes contribute to synovial inflammation in rheumatoid arthritis are poorly understood. Here we review data that indicate an important role for cell contact between synovial T cells, adjacent macrophages and fibroblast-like synoviocytes (FLS). Thus, T cells activated by cytokines, endothelial transmigration, extracellular matrix or by auto-antigens can promote cytokine, particularly TNFα, metalloproteinase production by macrophages and FLS through cell-membrane interactions, mediated at least through β-integrins and membrane cytokines. Since soluble factors thus induced may in turn contribute directly to T cell activation, positive feedback loops are likely to be created. These novel pathways represent exciting potential therapeutic targets. |
| distribution |
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| identifier | https://healthdata.gov/api/views/9ggk-s5pv |
| issued | 2025-07-14 |
| keyword |
[
"cell-interactions",
"nih",
"rheumatoid-arthritis",
"synovitis",
"t-lymphocytes"
]
|
| landingPage | https://healthdata.gov/d/9ggk-s5pv |
| modified | 2025-09-06 |
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| publisher |
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| theme |
[
"NIH"
]
|
| title | Cell-cell interactions in synovitis: Interactions between T lymphocytes and synovial cells |
