Found 15 datasets matching "synovitis".
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Cytokines and direct cell contact in synovitis: relevance to therapeutic intervention
Search relevance: 148.44 | Views last month: 0 -
The challenge of early synovitis: multiple pathways to a common clinical syndrome
Search relevance: 143.96 | Views last month: 0 -
An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine the clinical...
Search relevance: 122.52 | Views last month: 3 -
Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis...
Search relevance: 119.07 | Views last month: 0 -
The synovium lines the noncartilaginous surfaces of the diarthrodial joints, and synovial tissue is also found in tendon sheaths and bursae [1]. Several rheumatic diseases are characterized by...
Search relevance: 112.28 | Views last month: 0 -
Leukocyte ingress into the synovium is a key process in the pathogenesis of rheumatoid arthritis and other inflammatory conditions. In this review, the role of endothelial cells in leukocyte...
Search relevance: 96.47 | Views last month: 0 -
There is mounting evidence indicating that the synovial fibroblast is a direct effector of tissue injury and matrix remodeling in inflammatory synovitis. Through the elaboration of effector...
Search relevance: 84.99 | Views last month: 0 -
Mechanisms whereby T lymphocytes contribute to synovial inflammation in rheumatoid arthritis are poorly understood. Here we review data that indicate an important role for cell contact between...
Search relevance: 84.88 | Views last month: 1 -
In rheumatoid arthritis, T cells and B cells participate in the immune responses evolving in the synovial lesions. Interaction between T cells and B cells is probably antigen specific because...
Search relevance: 81.14 | Views last month: 0 -
Recent technological advances allow the transfer of genes to the synovial lining of joints. As well as opening novel opportunities for therapy, these techniques provide valuable new tools...
Search relevance: 72.45 | Views last month: 0 -
The synovial tissue in rheumatoid arthritis (RA) patients is enriched with mature antigen presenting cells (APCs) and many T lymphocytes. Interactions between APCs and T cells are essential for...
Search relevance: 55.56 | Views last month: 0 -
This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and...
Search relevance: 36.90 | Views last month: 1 -
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various...
Search relevance: 31.76 | Views last month: 0 -
Anti-tumor-necrosis-factor-α (TNF-α) monoclonal antibody was used to treat Tg197 transgenic mice, which constitutively produce human TNF-α (hTNF-α) and develop a progressive polyarthritic disease....
Search relevance: 27.99 | Views last month: 0 -
Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide...
Search relevance: 24.46 | Views last month: 1
