Found 10 datasets matching "gene-delivery".
-
Background Attempts at gene therapy for the pulmonary manifestations of Cystic Fibrosis have relied mainly on airway delivery. However the efficiency of gene transfer and expression in...
Search relevance: 215.26 | Views last month: 7 -
Background The hepatic stellate cell is the primary cell type responsible for the excessive formation and deposition of connective tissue elements during the development of hepatic...
Search relevance: 180.86 | Views last month: 2 -
To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mIL-4) was used for...
Search relevance: 114.18 | Views last month: 0 -
Recombinant adenoviruses are straightforward to produce at high titres, have a promiscuous host-range, and, because of their ability to infect nondividing cells, lend themselves to in vivo gene...
Search relevance: 110.51 | Views last month: 0 -
These data describe delivery of novel gene silencing agents (GSAs) to leaf tissue of the invasive common reed <i>Phragmites australis</i> ssp. <i>australis</i> using cell penetrating peptides...
Search relevance: 106.77 | Views last month: 0 -
Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation...
Search relevance: 50.07 | Views last month: 0 -
The ability of transfected synthetic small interfering (si) RNAs to suppress the expression of specific transcripts has proved a useful technique to probe gene function in mammalian cells....
Search relevance: 47.75 | Views last month: 0 -
Background This study tested a low-volume (20–30 μl/20–30 μg DNA) jet injection method for intradermal delivery of a DNA vaccine. Jet injection offers the advantages of a needle-less...
Search relevance: 46.87 | Views last month: 0 -
Background Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-defective adenoviral...
Search relevance: 46.83 | Views last month: 0 -
Respirable antisense oligonucleotides (RASONs), which attenuate specific disease-associated mRNAs, represent a new class of respiratory therapeutics with considerable potential. RASONs overcome...
Search relevance: 42.97 | Views last month: 1
