Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4
To determine whether IL-4 is therapeutic in treating established
experimental arthritis, a recombinant adenovirus carrying the gene that encodes
murine IL-4 (Ad-mIL-4) was used for periarticular injection into the ankle
joints into mice with established collagen-induced arthritis (CIA).
Periarticular injection of Ad-mIL-4 resulted in a reduction in the severity of
arthritis and joint swelling compared with saline- and adenoviral control
groups. Local expression of IL-4 also reduced macroscopic signs of joint
inflammation and bone erosion. Moreover, injection of Ad-mIL-4 into the hind
ankle joints resulted in a decrease in disease severity in the untreated front
paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mIL-4
resulted in a significant reduction in the severity of early-stage
arthritis.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"009:25"
]
|
| contactPoint |
{
"fn": "NIH",
"@type": "vcard:Contact",
"hasEmail": "mailto:info@nih.gov"
}
|
| description | To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mIL-4) was used for periarticular injection into the ankle joints into mice with established collagen-induced arthritis (CIA). Periarticular injection of Ad-mIL-4 resulted in a reduction in the severity of arthritis and joint swelling compared with saline- and adenoviral control groups. Local expression of IL-4 also reduced macroscopic signs of joint inflammation and bone erosion. Moreover, injection of Ad-mIL-4 into the hind ankle joints resulted in a decrease in disease severity in the untreated front paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mIL-4 resulted in a significant reduction in the severity of early-stage arthritis. |
| distribution |
[
{
"@type": "dcat:Distribution",
"title": "Official Government Data Source",
"mediaType": "text/html",
"description": "Visit the original government dataset for complete information, documentation, and data access.",
"downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17812/"
}
]
|
| identifier | https://healthdata.gov/api/views/25vc-57bg |
| issued | 2025-07-13 |
| keyword |
[
"collagen-induced-arthritis",
"gene-therapy",
"interleukin-4",
"murine-model",
"nih"
]
|
| landingPage | https://healthdata.gov/d/25vc-57bg |
| modified | 2025-09-06 |
| programCode |
[
"009:048"
]
|
| publisher |
{
"name": "National Institutes of Health",
"@type": "org:Organization"
}
|
| theme |
[
"NIH"
]
|
| title | Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4 |
