Found 12 datasets matching "interleukin-4".
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Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of...
Search relevance: 182.64 | Views last month: 0 -
Destruction of cartilage and bone are hallmarks of human rheumatoid arthritis (RA), and controlling these erosive processes is the most challenging objective in the treatment of RA....
Search relevance: 169.72 | Views last month: 1 -
The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to...
Search relevance: 136.58 | Views last month: 0 -
To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mIL-4) was used for...
Search relevance: 103.79 | Views last month: 0 -
Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2...
Search relevance: 45.18 | Views last month: 0 -
Background Inhalation of Ascaris suum antigen by allergic monkeys causes an immediate bronchoconstriction and delayed allergic reaction, including a pulmonary inflammatory infiltrate. To...
Search relevance: 40.91 | Views last month: 0 -
Background The development and activation of CD4+ helper T cell (Th) subsets with distinct patterns of unbalanced production of cytokines play an important part in infectious, allergic...
Search relevance: 36.29 | Views last month: 1 -
Background Helicobacter pylori is the main risk factor for the development of non-cardia gastric cancer. Increased proliferation of the gastric mucosa is a feature of H. pylori...
Search relevance: 31.98 | Views last month: 0 -
Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide...
Search relevance: 30.97 | Views last month: 1 -
We developed a cell culture exposure system (CCES) to expose cells at the air-liquid interface (ALI) to volatile chemicals. We characterized the CCES by exposing indigo dye-impregnated filters...
Search relevance: 28.55 | Views last month: 0 -
Background T cells from HIV+ and aged individuals show parallels in terms of suppressed proliferative activity and interleukin-2 (I1-2) production and an increased number of CD8+ CD28- T...
Search relevance: 28.13 | Views last month: 1 -
Radiation affects tissue and cellular integrity at the level of DNA protein and metabolites of the cell and extracellular space. The effects of radiation are not limited to targeted cells and...
Search relevance: 25.66 | Views last month: 0
