Found 27 datasets matching "in vitro-in vivo extrapolation".
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This dataset, presented as an Excel spreadsheet, contains all data presented as figures and tables in an article by Nichols et al, entitled "In vitro-in vivo extrapolation of hepatic...
Search relevance: 338.83 | Views last month: 1 -
All relevant data are within the manuscript, its Supporting Information files, and the httk R software package v1.9.2. This dataset is associated with the following publication: Honda, G., R....
Search relevance: 333.87 | Views last month: 0 -
This paper described development of an in vitro/in vivo model that accounts for first pass clearance effects. The model details are contained in the supporting information for the paper. This...
Search relevance: 186.78 | Views last month: 0 -
The purpose of is this study was to evaluate the potential for biotransformation in the gastrointestinal tissues (GIT) of fish to impact chemical bioaccumulation. In vitro biotransformation of...
Search relevance: 180.57 | Views last month: 0 -
We report on new, in vivo TK experiments in rats for 26 chemicals more commonly associated with non-therapeutic and/or unintentional exposure. These chemicals, and an additional 19 chemicals from...
Search relevance: 177.71 | Views last month: 0 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 156.14 | Views last month: 2 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 151.11 | Views last month: 1 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 151.11 | Views last month: 0 -
the data set contains the figures and tables from the publication in addition to the means, standard errors of the mean and the sample sizes used in each group for every experiment. the data set...
Search relevance: 95.19 | Views last month: 1 -
This repository contains the necessary data, python source code and jupyter notebooks to reproduce the results from our manuscript, "Estimating Hepatotoxic Doses Using High-content Imaging in...
Search relevance: 87.91 | Views last month: 5 -
This dataset provides measured in vitro intrinsic clearance rates for 54 chemicals tested using isolated hepatocytes from humans, rats, and rainbow trout. The test chemicals were selected to...
Search relevance: 85.51 | Views last month: 0 -
Data sets in the context of this project are the model files, model input parameter sets, and data generated at the US EPA/ORD/National Health and Environmental Effects Research Laboratory that...
Search relevance: 82.04 | Views last month: 0 -
This paper describes the results of an international ring trial (round robin study) of in vitro methods used to measure chemical biotransformation in fish. Researchers at six laboratories in the...
Search relevance: 81.65 | Views last month: 1 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 80.49 | Views last month: 1 -
The purpose of this study was to compare two in vitro systems, cryopreserved trout hepatocytes and trout liver S9 fractions, used to predict in vivo levels of biotransformation in fish. This...
Search relevance: 79.56 | Views last month: 0 -
This dataset describes the results of a set of experiments, the goal of which was to evaluate the effects of protease inhibitors on the trout liver S9 substrate depletion assay. The presented...
Search relevance: 78.95 | Views last month: 0 -
Supporting information in "Saunders, L.J. and Nichols, J.W. (2023), Models Used to Predict Chemical Bioaccumulation in Fish from in Vitro Biotransformation Rates Require Accurate Estimates of...
Search relevance: 78.86 | Views last month: 2 -
The dataset, which is presented as an Excel spreadsheet, contains all data which is presented as figures in Nichols et al., Measurement of kinetic parameters for biotransformation of polycyclic...
Search relevance: 77.02 | Views last month: 0 -
Supplementary files for "Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment"
Search relevance: 76.90 | Views last month: 0 -
This dataset contains model code and supporting analysis files necessary to evaluate the impact of variability in human hepatic scaling factors. Variation in scaling factor values impacts...
Search relevance: 76.01 | Views last month: 0
