Found 43 datasets matching "transduction".
-
We are developing retroviral-mediated gene transfer to human fibroblast-like synovial cells (FLS) as one approach to characterizing genetic pathways involved in synoviocyte pathophysiology. Prior...
Search relevance: 128.73 | Views last month: 0 -
Background Hedgehog signaling proteins play important roles in development by controlling growth and patterning in various animals including Drosophila and mammals. Hedgehog signaling...
Search relevance: 126.96 | Views last month: 0 -
This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An amphotropic retrovirus (MFG-IRAP) was...
Search relevance: 108.38 | Views last month: 3 -
Background Taste receptor cells are responsible for transducing chemical stimuli into electrical signals that lead to the sense of taste. An important second messenger in taste...
Search relevance: 79.87 | Views last month: 0 -
Background Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-defective adenoviral...
Search relevance: 73.32 | Views last month: 0 -
Background Two-component systems consisting of histidine kinases and their corresponding receivers are widespread in bacterial signal transduction. In the past few years, genes coding...
Search relevance: 68.24 | Views last month: 0 -
Background Numerous investigations demonstrate a novel role of thyroid hormone as a modulator of signal transduction. Protein kinase C (PKC) is critical to the mechanism by which thyroid...
Search relevance: 67.49 | Views last month: 0 -
Background Protein kinase C (PKC) has become a major focus among cell biologists interested in second-messenger signal transduction and much has been learned about differences in the...
Search relevance: 57.57 | Views last month: 0 -
Background The intracellular signaling events of the Bone Morphogenetic Proteins (BMPs) involve the R-Smad family members Smad1, Smad5, Smad8 and the Co-Smad, Smad4. Smads are currently...
Search relevance: 51.37 | Views last month: 0 -
Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation...
Search relevance: 42.41 | Views last month: 0 -
The cytokine tumour necrosis factor (TNF)α is a vital mediator of the innate immune response, and a pleiotropic regulator of cellular function. Its involvement in rheumatoid arthritis is...
Search relevance: 35.23 | Views last month: 0 -
Background Activation of human resting T lymphocytes results in an immediate increase in protein synthesis. The increase in protein synthesis after 16–24 h has been linked to the...
Search relevance: 35.05 | Views last month: 0 -
The aim of this study was to analyze the differential effects of three anti-CD4 monoclonal antibodies (mAbs) (with distinct epitope specifities) in the treatment of rat adjuvant arthritis (AA) and...
Search relevance: 33.17 | Views last month: 0 -
Data presented is part of abstract and poster titled "Entangling Superconducting Qubits over Optical Fiber ? Towards Optimization and Implementation" presented at "IEEE International Conference on...
Search relevance: 32.45 | Views last month: 0 -
Background In this study, we investigated the mechanism(s) by which delta opioids induce their potent activation of extracellular signal-regulated protein kinases (ERKs) in different...
Search relevance: 32.06 | Views last month: 0 -
Data presented is part of the journal manuscript "Optically Distributing Remote Two-node Microwave Entanglement using Doubly Parametric Quantum Transducers." Data includes graphical plots...
Search relevance: 31.79 | Views last month: 0 -
We examined molecular responses using transcriptome profiling in isolated left ventricular murine cardiomyocytes to 90 cGy, 1 GeV proton (1H) and 15 cGy, 1 GeV/nucleon (n) proton (56Fe) particles...
Search relevance: 31.49 | Views last month: 0 -
We examined molecular responses using transcriptome profiling in isolated left ventricular murine cardiomyocytes to 90 cGy, 1 GeV proton (1H) and 15 cGy, 1 GeV/nucleon (n) iron (56Fe) particles 1,...
Search relevance: 31.28 | Views last month: 0 -
The contribution of osteoclasts to the process of bone loss in inflammatory arthritis has recently been demonstrated. Studies in osteoclast biology have led to the identification of factors...
Search relevance: 30.88 | Views last month: 0 -
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various...
Search relevance: 30.16 | Views last month: 0
