Found 17 datasets matching "tumor-suppressor".
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Background The tumor suppressor gene PTEN has been found mutated in many types of advanced tumors. When introduced into tumor cells that lack the wild-type allele of the gene, exogenous...
Search relevance: 246.57 | Views last month: 0 -
Background NF1 refers to type 1 neurofibromatosis syndrome, which has been linked with mutations of the large NF1 gene. NF1 tumor suppressor protein, neurofibromin, has been shown to...
Search relevance: 167.86 | Views last month: 0 -
Abstract Here we have reviewed the conventional definitions and fundamental characteristics of the two basic types of stem cells, embryonic stem cells (ESCs) and somatic stem cells...
Search relevance: 127.55 | Views last month: 0 -
Background HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing transcription of...
Search relevance: 115.86 | Views last month: 1 -
Background Expression of the retinoic acid receptor β2 (RAR-β2), a putative tumor suppressor gene, is reduced in various human cancers, including squamous cell carcinomas (SCC) of the...
Search relevance: 105.17 | Views last month: 1 -
DLD-1 and MOLT-4 cell lines were cultured in a rotating cell culture system to simulate microgravity and mRNA expression profile in comparison to Static controls. Cells were grown in 10mL rotating...
Search relevance: 77.78 | Views last month: 0 -
Background Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive activation of Akt,...
Search relevance: 73.44 | Views last month: 0 -
DLD-1 and MOLT-4 cell lines were cultured in a Rotating cell culture system to simulate microgravity and mRNA expression profile was observed in comparison to Static controls. Cells were grown in...
Search relevance: 71.35 | Views last month: 0 -
p53 performs a plethora of activities, which are directed towards the maintenance of the genomic integrity and constitute its universal role as a tumor suppressor. 1000 to 10000 latent...
Search relevance: 67.02 | Views last month: 0 -
Background Mutations in the CHK2 gene at chromosome 22q12.1 have been reported in families with Li-Fraumeni syndrome. Chk2 is an effector kinase that is activated in response to DNA...
Search relevance: 61.20 | Views last month: 1 -
Background The p53 protein is activated by genotoxic stress, oncogene expression and during senescence, p53 transcriptionally activates genes involved in growth arrest and apoptosis. p53...
Search relevance: 60.91 | Views last month: 0 -
Background In sporadic ovarian cancer, we have previously reported allele loss at D6S193 (62%) on chromosome 6q27, which suggested the presence of a putative tumour suppressor gene....
Search relevance: 59.48 | Views last month: 0 -
Germline mutations in the tumor suppressorPTENpredispose human beings to breast cancer, and genetic and epigenetic alterations ofPTENare also detected in sporadic human breast cancer....
Search relevance: 59.46 | Views last month: 0 -
Background Loss of activity of tumor suppressor genes is considered a fundamental step in a genetic model of carcinogenesis. Altered expression of the p53 and the Deleted in Colon Cancer...
Search relevance: 58.33 | Views last month: 0 -
Background The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation...
Search relevance: 46.87 | Views last month: 0 -
Background The growth and metastasis of tumors depend on the development of an adequate blood supply via angiogenesis. Recent studies indicate that the inducible nitric oxide synthase...
Search relevance: 46.24 | Views last month: 0 -
Transforming growth factor beta-1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis, but it can switch to a tumor promoter during neoplastic progression. Ionizing radiation...
Search relevance: 33.41 | Views last month: 1
