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Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system
The ToxCast program has generated in vitro screening data on over a thousand chemicals to assess potential disruption of important biological processes and assist in hazard identification and chemical testing prioritization. Few results have been reported for complex mixtures. To extend these ToxCast efforts to mixtures, we tested extracts from 30 organically grown fruits and vegetables in concentration-response in the BioMAP® assays. BioMAP systems use human primary cells primed with endogenous pathway activators to identify phenotypic perturbations related to proliferation, inflammation, immunomodulation, and tissue remodeling.
This dataset is associated with the following publication:
Wetmore, B., R. Clewell, B. Cholewa, B. Parks, S. Pendse, M. Black, K. Mansouri, S. Haider, E. Berg, R. Judson, K. Houck, M. Martin, H. Clewell III, M. Andersen, R. Thomas, and P. McMullen. Assessing Bioactivity-Exposure Profiles of Fruits and Vegetables in the BioMAP Profiling System. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 54: 41-57, (2019).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Alexander Hanf",
"hasEmail": "mailto:hanf.alexander@epa.gov"
}
|
| description | The ToxCast program has generated in vitro screening data on over a thousand chemicals to assess potential disruption of important biological processes and assist in hazard identification and chemical testing prioritization. Few results have been reported for complex mixtures. To extend these ToxCast efforts to mixtures, we tested extracts from 30 organically grown fruits and vegetables in concentration-response in the BioMAP® assays. BioMAP systems use human primary cells primed with endogenous pathway activators to identify phenotypic perturbations related to proliferation, inflammation, immunomodulation, and tissue remodeling. This dataset is associated with the following publication: Wetmore, B., R. Clewell, B. Cholewa, B. Parks, S. Pendse, M. Black, K. Mansouri, S. Haider, E. Berg, R. Judson, K. Houck, M. Martin, H. Clewell III, M. Andersen, R. Thomas, and P. McMullen. Assessing Bioactivity-Exposure Profiles of Fruits and Vegetables in the BioMAP Profiling System. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 54: 41-57, (2019). |
| distribution |
[
{
"title": "https://doi.org/10.1016/j.tiv.2018.09.006",
"accessURL": "https://doi.org/10.1016/j.tiv.2018.09.006"
}
]
|
| identifier | https://doi.org/10.23719/1504521 |
| keyword |
[
"ExpoCast",
"Natural products",
"ToxCast",
"bioactivity",
"exposure",
"high-throughput"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2018-03-19 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1016/j.tiv.2018.09.006"
]
|
| rights |
null
|
| title | Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system |
