Data for: Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays
This dataset contains the raw data, Area under the curve measurements and EC50 values for effects of 146 compounds (136 unique plus 10 biological replicates) on parameters of network development measured in vitro. There are 17 parameters plus 2 measures of viability. In addition, the data for the ranking of potency and selectivity are provided, as well as data for the comparisons to other ToxCast assays and in vitro to in vivo extrapolations.
This dataset is associated with the following publication:
Shafer, T., J. Brown, B. Lynch, S. Davila-Montero, K. Wallace, and K. Paul-Friedman. Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 169(2): 436-455, (2019).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Timothy Shafer",
"hasEmail": "mailto:shafer.tim@epa.gov"
}
|
| description | This dataset contains the raw data, Area under the curve measurements and EC50 values for effects of 146 compounds (136 unique plus 10 biological replicates) on parameters of network development measured in vitro. There are 17 parameters plus 2 measures of viability. In addition, the data for the ranking of potency and selectivity are provided, as well as data for the comparisons to other ToxCast assays and in vitro to in vivo extrapolations. This dataset is associated with the following publication: Shafer, T., J. Brown, B. Lynch, S. Davila-Montero, K. Wallace, and K. Paul-Friedman. Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 169(2): 436-455, (2019). |
| distribution |
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"title": "Excel scatter plot potency vs viability_Nov_26_2018.xlsx",
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"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503191/Excel%20scatter%20plot%20potency%20vs%20viability_Nov_26_2018.xlsx"
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|
| identifier | https://doi.org/10.23719/1503191 |
| keyword |
[
"Chemical Screening",
"In vitro assay",
"Microelectrode array",
"developmental neurotoxicity"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2018-11-26 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1093/toxsci/kfz052"
]
|
| rights |
null
|
| title | Data for: Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays |
