Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library
The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist activity. Active compounds were further characterized using additional orthogonal assays, including mammalian one-hybrid assays, coactivator recruitment assays, and a high-throughput, fluorescent imaging, nuclear receptor translocation assay. Results for the library are available at https://tripod.nih.gov/tox21/samples.
This dataset is associated with the following publication:
Paul-Friedman, K., M. Martin, K. Crofton, C. Hsu, S. Sakamuru, J. Zhao, M. Xia, R. Huang, D. Stevreva, V. Soni, L. Varticovski, R. Raziuddin, G. Hager, and K. Houck. Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 127(9): 1-16, (2019).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
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| contactPoint |
{
"fn": "Keith Houck",
"hasEmail": "mailto:houck.keith@epa.gov"
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| description | The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist activity. Active compounds were further characterized using additional orthogonal assays, including mammalian one-hybrid assays, coactivator recruitment assays, and a high-throughput, fluorescent imaging, nuclear receptor translocation assay. Results for the library are available at https://tripod.nih.gov/tox21/samples. This dataset is associated with the following publication: Paul-Friedman, K., M. Martin, K. Crofton, C. Hsu, S. Sakamuru, J. Zhao, M. Xia, R. Huang, D. Stevreva, V. Soni, L. Varticovski, R. Raziuddin, G. Hager, and K. Houck. Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 127(9): 1-16, (2019). |
| distribution |
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"title": "SupplementalTables_clearance.xlsx",
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|
| identifier | https://doi.org/10.23719/1503082 |
| keyword |
[
"High throughput screening",
"Tox21",
"ToxCast",
"endocrine disruption",
"high throughput toxicology",
"thyroid hormone receptors"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2019-03-05 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
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|
| references |
[
"https://doi.org/10.1289/ehp5314"
]
|
| rights |
null
|
| title | Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library |
