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Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals
Screening certain environmental chemicals for their ability to interact with endocrine targets, including the androgen receptor (AR), is an important global concern. We previously developed a model using a battery of eleven in vitro AR assays to predict in vivo AR activity. Here we describe a revised mathematical modelling approach that also incorporates data from newly available assays and demonstrate that subsets of assays can provide close to the same level of predictivity. These subset models are evaluated against the full model using 1820 chemicals, as well as in vitro and in vivo reference chemicals from the literature.
This dataset is associated with the following publication:
Judson, R., K. Houck, K. Friedman, J. Brown, P. Browne, P. Johnston, D. Close, K. Mansouri, and N. Kleinstreuer. Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 117(November 2020): 104764, (2020).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Keith Houck",
"hasEmail": "mailto:houck.keith@epa.gov"
}
|
| description | Screening certain environmental chemicals for their ability to interact with endocrine targets, including the androgen receptor (AR), is an important global concern. We previously developed a model using a battery of eleven in vitro AR assays to predict in vivo AR activity. Here we describe a revised mathematical modelling approach that also incorporates data from newly available assays and demonstrate that subsets of assays can provide close to the same level of predictivity. These subset models are evaluated against the full model using 1820 chemicals, as well as in vitro and in vivo reference chemicals from the literature. This dataset is associated with the following publication: Judson, R., K. Houck, K. Friedman, J. Brown, P. Browne, P. Johnston, D. Close, K. Mansouri, and N. Kleinstreuer. Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 117(November 2020): 104764, (2020). |
| distribution |
[
{
"title": "https://gaftp.epa.gov/COMPTOX/STAFF/rjudson/publications/Judson%20AR%202019/",
"accessURL": "https://gaftp.epa.gov/COMPTOX/STAFF/rjudson/publications/Judson%20AR%202019/"
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|
| identifier | https://doi.org/10.23719/1504530 |
| keyword |
[
"Androgen receptor",
"High throughput screening",
"ToxCast",
"alternative testing methods",
"endocrine disruption",
"high throughput toxicology",
"in vitro"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2019-11-18 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1016/j.yrtph.2020.104764"
]
|
| rights |
null
|
| title | Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals |
