Structural Malformations in Brain Accompany Developmental Perchlorate Exposure in Rodents
Structural defects in the rat brain associated with maternal exposure to ammonium perchlorate accompanied reductions in circulating levels of thyroid hormone in the dam and the fetus. The magnitude of the effect was small relative to other thyroid hormone disruptors, but his was due to the lack of sufficient bioavailability of perchlorate to the nursing neonate. When pups were administered perchlorate directly for the first 6 days of life or if perchlorate was administered under conditions of maternal dietary iodine deficiency, very large brain malformations were induced.
This dataset is associated with the following publication:
Gilbert, M., K. O'Shaughnessy, K. Bell, and J. Ford. Structural Malformations in the Neonatal Rat Brain Accompany Developmental Exposure to Ammonium Perchlorate. Toxics. MDPI, Basel, SWITZERLAND, 11(12): 1027, (2023).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Mary Gilbert",
"hasEmail": "mailto:gilbert.mary@epa.gov"
}
|
| description | Structural defects in the rat brain associated with maternal exposure to ammonium perchlorate accompanied reductions in circulating levels of thyroid hormone in the dam and the fetus. The magnitude of the effect was small relative to other thyroid hormone disruptors, but his was due to the lack of sufficient bioavailability of perchlorate to the nursing neonate. When pups were administered perchlorate directly for the first 6 days of life or if perchlorate was administered under conditions of maternal dietary iodine deficiency, very large brain malformations were induced. This dataset is associated with the following publication: Gilbert, M., K. O'Shaughnessy, K. Bell, and J. Ford. Structural Malformations in the Neonatal Rat Brain Accompany Developmental Exposure to Ammonium Perchlorate. Toxics. MDPI, Basel, SWITZERLAND, 11(12): 1027, (2023). |
| distribution |
[
{
"title": "ScienceHub Dev DirectDose IDPer PVH.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531741/ScienceHub%20Dev%20DirectDose%20IDPer%20PVH.xlsx"
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|
| identifier | https://doi.org/10.23719/1531741 |
| keyword |
[
"Adverse Outcome Pathways (AOPs)",
"Children's Environmental Health",
"Environmental Justice",
"developmental neurotoxicity",
"endocrine disrupting chemicals",
"in vivo",
"thyroid"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2024-09-19 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.3390/toxics11121027",
"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10747616"
]
|
| rights |
null
|
| title | Structural Malformations in Brain Accompany Developmental Perchlorate Exposure in Rodents |
