Found 16 datasets matching "Pharmacokinetic Model".
-
This data set includes source code files and associated data files that implement a pharmacokinetic (PK) model for lipophilic persistent environmental chemicals (LPECs) that can be used to...
Search relevance: 195.30 | Views last month: 0 -
Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific...
Search relevance: 126.73 | Views last month: 1 -
General aggregate PFOS and PFOA exposure estimates are based on reported summary statistics from concentration studies by media, i.e. into indoor air, outdoor air, food, water, dust and soil, and...
Search relevance: 114.04 | Views last month: 2 -
This ScienceHub entry contains a zip file with the pharmacokinetic modeling code used for the linked publication, "Challenges for extrapolation of risk from ingestion to inhalation exposure for...
Search relevance: 69.40 | Views last month: 0 -
This dataset contains physiologically-based (PBPK) model code and parameter settings supporting the manuscript titled "THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC...
Search relevance: 59.76 | Views last month: 2 -
The data set includes source code for a "PBPK model template" that can be used to implement physiologically based pharmacokinetic (PBPK) models with various different structural designs and...
Search relevance: 53.06 | Views last month: 1 -
Estimates of ionization equilibrium constants (i.e., pKa) were analyzed for 8,132 pharmaceuticals and 24,281 other compounds to which humans might be exposed in the environment. Results revealed...
Search relevance: 48.27 | Views last month: 0 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 43.40 | Views last month: 1 -
Generic physiologically-based pharmacokinetic (PBPK) models were used to explore how saturable absorption or clearance can influence the shape of the internal to external concentration (IEC)...
Search relevance: 42.67 | Views last month: 1 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 40.77 | Views last month: 1 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 40.77 | Views last month: 0 -
Background The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that is required for...
Search relevance: 40.40 | Views last month: 0 -
The US EPA Toxicity Forecasting (ToxCast) project has involved the generation of large amount of high throughput in vitro data (Over 4000 chemicals tested in between 100 and 700 assays). This data...
Search relevance: 37.64 | Views last month: 0 -
This ScienceHub entry was developed for the published paper: Consoer et al., 2016, Toxicokinetics of perfluorooctane sulfonate in rainow trout (Oncorhynchus mykiss), Environ. Toxicol. Chem....
Search relevance: 35.79 | Views last month: 2 -
Exposure of wildlife to Active Pharmaceutical Ingredients (APIs) is likely to occur but evidence of hazard and risk is limited. One exposure pathway that has received attention is trophic transfer...
Search relevance: 31.51 | Views last month: 1
