Found 93 datasets matching "chromosome".
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We propose that the phenomenon of X-chromosome inactivation in females may constitute a risk factor for loss of T-cell tolerance; specifically that skewed X-chromosome inactivation in the thymus...
Search relevance: 145.14 | Views last month: 2 -
“Functional wasteland,” “Nonrecombining desert,” and “Gene-poor chromosome” are only some examples of the different definitions given to the Y chromosome in the last decade. In comparison to the...
Search relevance: 140.16 | Views last month: 0 -
The role of X-chromosome inactivation in female predispositionto autoimmunity
Search relevance: 132.63 | Views last month: 0 -
Background Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disorder characterized by the weakness of facial, shoulder-girdle and upper arm muscles. Most patients...
Search relevance: 128.63 | Views last month: 0 -
We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found,...
Search relevance: 121.62 | Views last month: 2 -
Background Proximal chromosome 15q is implicated in neurodevelopmental disorders including Prader-Willi and Angelman syndromes, autistic disorder and developmental abnormalities...
Search relevance: 110.43 | Views last month: 3 -
Background The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease, was previously mapped to chromosome 16p12-q21. However, inconsistent physical maps of the region...
Search relevance: 109.75 | Views last month: 1 -
The olive fruit fly, Bactrocera oleae (Rossi) (Diptera: Tephritidae), is a specialist of fruits of the genus Olea and is a major pest of commercial olives due to their adverse impacts to olive...
Search relevance: 105.27 | Views last month: 1 -
The Trojan Y Chromosome (TYC) strategy is a promising eradication method for biological control of non-native species. The strategy works by manipulating the sex ratio of a population through the...
Search relevance: 91.56 | Views last month: 0 -
Within this dataset: Genome assembly of Linum lewisii (NDSU_LiLewi_1.0.fasta) First 9 scaffolds represent all 9 chromosomes (e.g. Scaffold_1 is Chromosome 1, Scaffold_9 is Chromosome...
Search relevance: 80.13 | Views last month: 1 -
Background Desmuslin is an α-dystrobrevin-interacting protein expressed primarily in heart and skeletal muscle. The desmuslin protein interacts with and is closely related to desmin, a...
Search relevance: 79.52 | Views last month: 2 -
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to a wide range of self-antigens. Recent genome screens have implicated...
Search relevance: 78.94 | Views last month: 0 -
Genome sequence with gene annotation files of the creeping bentgrass cultivar 'Declaration' genome assembly reported in the manuscript "Haplotype-resolved chromosome-level genome assembly of...
Search relevance: 76.90 | Views last month: 0 -
Genome-wide linkage analysis studies in families with systemic lupus erythematosus (SLE) have revealed consistent evidence of linkage to several regions of the genome. In a previous issue of this...
Search relevance: 74.43 | Views last month: 0 -
Background In most organisms proper reductional chromosome segregation during meiosis I is strongly correlated with the presence of crossover recombination structures (chiasmata);...
Search relevance: 71.00 | Views last month: 0 -
Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on...
Search relevance: 68.67 | Views last month: 1 -
Background Rab GTPases are regulators of intracellular membrane traffic. The Rab27 subfamily consists of Rab27a and Rab27b. Rab27a has been recently implicated in Griscelli Disease, a...
Search relevance: 66.61 | Views last month: 0 -
Background Genetic screens in Drosophila have provided a wealth of information about a variety of cellular and developmental processes. It is now possible to screen for mutant phenotypes...
Search relevance: 66.61 | Views last month: 0 -
Background Capping protein (CP), a heterodimer of α and β subunits, is found in all eukaryotes. CP binds to the barbed ends of actin filaments in vitro and controls actin assembly and...
Search relevance: 59.66 | Views last month: 0 -
Background Familial atrial fibrillation, an autosomal dominant disease, was previously mapped to chromosome 10q22. One of the genes mapped to the 10q22 region is DLG5, a member of the...
Search relevance: 58.14 | Views last month: 0
