Found 21 datasets matching "endocrine activity".
-
Data set to support the manuscript "Increased endocrine activity of xenobiotic chemicals as mediated by metabolic activation". Contains analytical measurement of metabolites, binding potential to...
Search relevance: 151.99 | Views last month: 1 -
Dataset consists of high throughput in vitro bioactivity data and exposure predictions from the U.S. EPA’s Toxicity and Exposure Forecaster (ToxCast and ExpoCast) project. This dataset is...
Search relevance: 134.96 | Views last month: 1 -
Although endocrine disrupting compounds have been detected in wastewater and surface waters worldwide using a variety of in vitro effects-based screening tools, e.g. bioassays, few have examined...
Search relevance: 59.48 | Views last month: 0 -
The data presented include concentrations of 122 organic, 23 inorganic constituents, and estrogenicity in water collected from 13 off-stream non-point source sites (natural and created wetlands)...
Search relevance: 58.50 | Views last month: 0 -
behavioral measures of learning and memory in adult offspring of rats treated with thyroid hormone synthesis inhibitor, propylthiouracil. Electrophysiological measures of 'memory' in form of...
Search relevance: 52.06 | Views last month: 0 -
A diverse data set of 1667 chemicals with AR experimental activity were provided by the U.S. EPA from the oxicity Forecaster (ToxCast) program which generates data using in vitro high-throughput...
Search relevance: 51.97 | Views last month: 0 -
Supporting data for "A chemical prioritization process: Applications to contaminants of emerging concern in freshwater ecosystems (Phase 1)". These data describe contaminants of emerging concern...
Search relevance: 49.96 | Views last month: 1 -
Intersex in small- and largemouth bass has been observed in the upper Chesapeake Bay Watershed since 2003. This observation is indicative of exposure to estrogenic endocrine disrupting chemicals....
Search relevance: 47.68 | Views last month: 0 -
Adult and young of the year smallmouth bass from the Chesapeake Bay watershed have faced health issues (mortality events, disease by a variety of pathogens, endocrine disruption in male fish,...
Search relevance: 45.04 | Views last month: 0 -
Background: Chemical toxicity testing is being transformed by advances in biology and computer modeling, concerns over animal use and the thousands of environmental chemicals lacking toxicity...
Search relevance: 44.87 | Views last month: 6 -
We have adapted two commonly used human breast luciferase transactivation cell bioassays, the recently re-named estrogen agonist/antagonist screening VM7Luc4E2 cell bioassay (previously designated...
Search relevance: 44.56 | Views last month: 0 -
The dataset contain the primary mutagenicity data. It consists of the number of mutant colonies (called revertants) per petri plate at each dose of the water extract as used in the Salmonella...
Search relevance: 44.01 | Views last month: 1 -
Screening certain environmental chemicals for their ability to interact with endocrine targets, including the androgen receptor (AR), is an important global concern. We previously developed a...
Search relevance: 43.34 | Views last month: 0 -
This high-throughput method will be useful in rapid evaluation of chemicals for nuclear receptor activity for multiple species of interest. The modular design of the assay also permits ready...
Search relevance: 42.34 | Views last month: 0 -
This dataset provides measured in vitro intrinsic clearance rates for 54 chemicals tested using isolated hepatocytes from humans, rats, and rainbow trout. The test chemicals were selected to...
Search relevance: 39.83 | Views last month: 0 -
Data from study assessing the utility of knowledgebase-leveraging of comprehensive environmental-contaminant-exposure datasets by comparing biological effects predicted on the basis of target...
Search relevance: 39.77 | Views last month: 1 -
The foundation of this study was based on a sediment quality triad (SQT) approach with a probabilistic sampling design, which characterized the estuary in terms of chemical contamination in...
Search relevance: 39.29 | Views last month: 0 -
As a case study, chemical occurrence data from a 2012 study in the Great Lakes Basin along with the ToxCast™ effects database were used to calculate exposure-activity ratios (EARs) as a...
Search relevance: 37.83 | Views last month: 0 -
Water and sediment was collected to assess the occurrence of contaminants of emerging concern (CECs) in National Park waters of the northern Colorado Plateau, USA. CEC presence in water and...
Search relevance: 35.61 | Views last month: 0 -
There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme involved in the...
Search relevance: 34.33 | Views last month: 1
