Found 35 datasets matching "extracellular-matrix".
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Cartilage contains numerous noncollagenous proteins in its extracellular matrix, including proteoglycans. At least 40 such molecules have been identified, differing greatly in structure,...
Search relevance: 198.46 | Views last month: 0 -
A method and composition are provided for inducing or enhancing chondrogenesis in vivo or in vitro. The method is performed by exposing the cells in vitro or in vivo to an extracellular matrix...
Search relevance: 143.71 | Views last month: 0 -
Background The membrane-bound cell-surface precursor and soluble forms of heparin-binding epidermal growth factor-like growth factor (HB-EGF) contribute to many cellular developmental...
Search relevance: 124.93 | Views last month: 0 -
Background During wound repair, fibroblasts orchestrate replacement of the provisional matrix formed during clotting with tenascin, cellular fibronectin and collagen III. These, in turn,...
Search relevance: 106.88 | Views last month: 0 -
Background The relationship between cell shape, proliferation, and extracellular matrix (ECM) production, important aspects of cell behavior, is examined in a little-studied cell type,...
Search relevance: 91.84 | Views last month: 0 -
Background Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes...
Search relevance: 78.28 | Views last month: 0 -
A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise oligonucleotides specific for nuclear proto-oncogenes....
Search relevance: 72.38 | Views last month: 0 -
Fibroblast-like cells in the synovial lining (type B lining cells), stroma and pannus tissue are targeted by many signals, such as the following: ligands binding to cell surface receptors; lipid...
Search relevance: 66.68 | Views last month: 1 -
Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these...
Search relevance: 65.77 | Views last month: 0 -
This dataset provides information on the viability of organotypic approaches in evaluating extracellular vesicles (EVs) to investigate exposure-induced biomarkers and underlying mechanisms. Data...
Search relevance: 63.18 | Views last month: 0 -
Background The iridocorneal angle forms in the mammalian eye from undifferentiated mesenchyme between the root of the iris and cornea. A major component is the trabecular meshwork,...
Search relevance: 57.92 | Views last month: 0 -
The extracellular matrix is essential for the integrity of the lung and when disrupted can lead to the architectural changes seen in emphysema. The etiology of emphysema is believed to be due to...
Search relevance: 56.99 | Views last month: 0 -
Background Mechanisms regulating neuronal migration during development remain largely undefined. Extracellular matrix cues, target site released factors, and components of the migratory...
Search relevance: 56.17 | Views last month: 0 -
Background SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the...
Search relevance: 55.45 | Views last month: 0 -
Cartilage serves multiple functions in the developing embryo and in postnatal life. Genetic mutations affecting cartilage development are relatively common and lead to skeletal malformations,...
Search relevance: 54.77 | Views last month: 1 -
The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III,...
Search relevance: 54.14 | Views last month: 0 -
Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promotes bone growth....
Search relevance: 53.25 | Views last month: 0 -
Organogenesis in the embryo involves cell differentiation and organization events that are unique to each tissue and organ and are susceptible to developmental toxicants. Animal models are the...
Search relevance: 51.91 | Views last month: 1 -
Mechanisms whereby T lymphocytes contribute to synovial inflammation in rheumatoid arthritis are poorly understood. Here we review data that indicate an important role for cell contact between...
Search relevance: 50.05 | Views last month: 1 -
There is growing evidence that activated synovial fibroblasts, as part of a complex cellular network, play an important role in the pathogenesis of rheumatoid arthritis. In recent years,...
Search relevance: 49.75 | Views last month: 0
