• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

The synovial tissue in rheumatoid arthritis (RA) patients is enriched with mature antigen presenting cells (APCs) and many T lymphocytes. Interactions between APCs and T cells are essential for...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Mechanisms whereby T lymphocytes contribute to synovial inflammation in rheumatoid arthritis are poorly understood. Here we review data that indicate an important role for cell contact between...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

A study was done to determine if the differentiation and activation phenotype of T cells in synovial fluid (SF) from patients with juvenile idiopathic arthritis (JIA) is associated with T-cell...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background Gene expression is affected by population density. Cell density is a potent negative regulator of cell cycle time during exponential growth. Here, we asked whether SV40 large...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

In rheumatoid arthritis, T cells and B cells participate in the immune responses evolving in the synovial lesions. Interaction between T cells and B cells is probably antigen specific because...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

The invention relates to the identification of epitopes for T-cells in human EPO as well as T-cell epitope peptides derived from EPO by means of which it is possible to create novel modified EPO...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background Various microbial, inflammatory and immune signals regulate the activation of dendritic cells (DC), determining their ability to interact with naïve T cells and to produce...

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• Organization: Department of Agriculture
• Updated: 2024-07-09

T-cell epitopes represent sampled environmental- and self-peptides loaded into major histocompatibility complex (MHC) proteins. Bioinformatic tools have been produced to predict these interactions...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Inflammatory responses provoked by pathogens are antigen-specific in their induction but are nonspecific in their effects. Consequently, they are potentially damaging to the host that produces...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-01

This study tested the hypothesis that transcription of immediate early genes is inhibited in T cells activated in microgravity (uG). Immunosuppression during spaceflight is a major barrier to safe...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

After activation CD4+ helper T cells differentiate into T-helper (Th) 1 or Th2 effector cells. These two subsets are characterized by their distinct cytokine expression pattern and the immune...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

This study tested the hypothesis that transcription of immediate early genes is inhibited in T cells activated in microgravity (uG). Immunosuppression during spaceflight is a major barrier to safe...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

This study tested the hypothesis that transcription of immediate early genes is inhibited in T cells activated in microgravity (mg). Immunosuppression during spaceflight is a major barrier to safe...

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• Organization: U.S. Environmental Protection Agency
• Updated: 2016-05-23

Dosing information, body weights during exposure and immune system endpoints. This dataset is associated with the following publication: DeWitt, J., W. Williams , J. Creech, and R. Luebke....

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

This invention relates to a novel approach for identification of T-cell epitopes, that give rise to an immune reaction in a living host. By means of this novel method biological compounds can be...

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• Organization: Department of Agriculture
• Updated: 2025-08-18

The dataset contains measurements from a swine research study evaluating influenza A immune responses and protection for replicon particle and live attenuated influenza virus vaccines. The...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Most patients with rheumatoid arthritis (RA) express HLA-DR4, HLA-DR1 or HLA-DR10. These alleles share a common amino acid motif in their third hypervariable regions: the shared epitope. In...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-defective adenoviral...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases. For most Tec kinases, this...

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