Found 48 datasets matching "gene-transfer".
-
Background Gene fusions can be used as tools for functional prediction and also as evolutionary markers. Fused genes often show a scattered phyletic distribution, which suggests a role...
Search relevance: 198.57 | Views last month: 3 -
Background Ribosomal proteins are encoded in all genomes of cellular life forms and are, generally, well conserved during evolution. In prokaryotes, the genes for most ribosomal proteins...
Search relevance: 179.34 | Views last month: 1 -
Background Glutathione is found primarily in eukaryotes and in Gram-negative bacteria. It has been proposed that eukaryotes acquired the genes for glutathione biosynthesis from the...
Search relevance: 176.50 | Views last month: 0 -
Background Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-defective adenoviral...
Search relevance: 173.40 | Views last month: 0 -
Background Electroporation of skeletal muscle after injection of naked DNA was shown by others to increase transgene expression. Information regarding tissue damage caused by...
Search relevance: 172.33 | Views last month: 0 -
Recent technological advances allow the transfer of genes to the synovial lining of joints. As well as opening novel opportunities for therapy, these techniques provide valuable new tools...
Search relevance: 142.84 | Views last month: 0 -
Conjugation efficiency of Salmonella Genomic Island 4 (SGI-4) from donor Salmonella enterica serovar I 4,[5],12:i:- or a plasmid containing oriTSGI-4 to recipient strain Salmonella enterica...
Search relevance: 141.80 | Views last month: 1 -
Background The outgrowth of new vessels – angiogenesis – in the tumour mass is considered to be a limiting factor of tumour growth. To inhibit the matrix lysis that is part of the tumour...
Search relevance: 132.58 | Views last month: 0 -
Conjugation efficiency of Salmonella Genomic Island 4 (SGI-4) from donor Salmonella enterica serovar I 4,[5],12:i:- strain BBS 1356 or a plasmid containing oriTSGI-4_966 from donor Salmonella...
Search relevance: 128.69 | Views last month: 0 -
Background: Genome comparisons have revealed major lateral gene transfer between the three primary kingdoms of life - Bacteria, Archaea, and Eukarya. Another important evolutionary...
Search relevance: 106.72 | Views last month: 1 -
Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation...
Search relevance: 100.99 | Views last month: 0 -
Background The p16INK4A gene product halts cell proliferation by preventing phosphorylation of the Rb protein. The p16INK4a gene is often deleted in human glioblastoma multiforme,...
Search relevance: 97.38 | Views last month: 1 -
This repository includes the raw data, analysis code, and results of a systematic analysis of natural transformation (i.e., horizontal gene transfer; HGT) of bacteria in a naturally occurring...
Search relevance: 95.68 | Views last month: 0 -
Background Genomic sequence analyses have shown that horizontal gene transfer occurred during the origin of eukaryotes as a consequence of symbiosis. However, details of the timing and...
Search relevance: 89.12 | Views last month: 0 -
The present invention relates to a transposon-based DNA integration system comprising (a) a transposon which is devoid of a polynucleotide encoding a functional transposase and which comprises a...
Search relevance: 80.39 | Views last month: 0 -
Background Horizontal gene transfer (HGT) played an important role in shaping microbial genomes. In addition to genes under sporadic selection, HGT also affects housekeeping genes and...
Search relevance: 71.08 | Views last month: 0 -
Background The hepatic stellate cell is the primary cell type responsible for the excessive formation and deposition of connective tissue elements during the development of hepatic...
Search relevance: 58.39 | Views last month: 2 -
The field of gene therapy for bone and joint disorders has grown considerably over the last two and a half years. Investigators have shown that ex vivo or in vivo gene transfer is highly effective...
Search relevance: 58.34 | Views last month: 0 -
The identification of the cystic fibrosis (CF) gene opened the way for gene therapy. In the ten years since then, proof of principle in vitro and then in animal models in vivo has been followed by...
Search relevance: 57.16 | Views last month: 2 -
Background The availability of multiple complete genome sequences from diverse taxa prompts the development of new phylogenetic approaches, which attempt to incorporate information...
Search relevance: 55.76 | Views last month: 2
